Relationship Between Subclinical Hypothyroidism And Factors Associated With Coronary Heart Disease And Coronary Artery Lesions

Objective:1. To investigate the effect of Subclinical hypothyroidism on biochemical indexes related to coronary heart disease, hypertension, diabetes, left ventricular end diastolic diameter and ejection fraction, and so on.2. To explore the relationship between Subclinical hypothyroidism and the severity of coronary lesions(Coronary count and Gensini score). Methods:This was a retrospective study. There were 248 subjects which were selected from the department of cardiology in the first hospital of Jilin University from November 2015 to January 2016, both to make coronary arteriography examination. According to the Thyroid function’s grouping, SH 95 cases, normal thyroid function 153 cases. Make a diagnosis of CHD by coronary arteriography 166 cases, CHD with SH 78 cases, normal thyroid function 88 cases.1. Collecting general clinical patients’ data, including their age, sex, hypertension, diabetes, smoking history, drinking history, history of the tumor, severe disease of heart head blood-vessel(Myocardial infarction, cerebral hemorrhage).2. Their venous blood biochemical indicators were measured on the second morning: TSH, FT4, FT3, FPG, the lipid indices(TC, TG, LDL-C, HDL-C), urea nitrogen, creatinine, uric acid, hemoglobin, fibrinogen, bilirubin, MPV, RDW, and echocardiography used to measure left ventricular end diastolic diameter and ejection fraction, and to compare the difference between the two groups.3. Further CHD with SH group can be sectionalized three subgroups including single lesion group, the double branch lesions and the multivessel lesion group, and to compare between TSH and group relations and the correlation between each index.4. In the CHD with SH group, according to the results of coronary angiography, we calculated the patients’ Gensini score, the three groups were divided(A group: Gensini score less than 30 score; B group: between 30 score and 60 score; C group: greater than 60 score), and to compare the difference between three groups. Results:1. Compared with the contrast, There are relationships between SH group and normal thyroid function group:(1). Compared with the normal thyroid function group, the SH group had a higher level of cholesterol than the normal thyroid function group(statistical analysis P<0.05). The two groups have difference in the LDL levels(statistical analysis P<0.05).(2). The SH group had a higher level of blood urea nitrogen than the normal thyroid function group(statistical analysis P<0.05). During the two groups, there is no Significant differences(P>0.05) in the other aspects, ejection fraction and left ventricular end diastolic diameter.(3). Compared with the normal thyroid function group, the SH group had a higher level of the morbidity of CHD(P<0.05).(4). In the Gensini score, the SH group had a higher level of the Gensini score(P<0.05).2. Further CHD with SH group can be sectionalized three subgroups including single lesion group, we can draw the following results:(1). Compared with the single lesion group, multivessel lesions and the double branch lesions were higher cholesterol levels(P<0.05).(2). In the Gensini score,multivessel lesions had a higher level of the Gensini score than double and single lesion group(P<0.05), and the double branch lesions were higher than single lesion group(P<0.05).(3). Multivessel lesions had a higher level of TSH levels than double and single lesion group.(P<0.05).3. In the CHD with SH group,according to the results of coronary angiography, we calculated the patients’ Gensini score and divide into three groups, we can get the following results:(1). According to the groups of patients’ Gensini score, We found C group were higher than A group In the aspect of TC(P<0.05). At the same time, the C group had a lower level of HDL levels than A group and B group(P<0.05).(2). In the TSH levels,the C group had a greater level than A group and B group(P<0.05).(3). Compared with the contrast, the C group and B group had a higher level of CR levels than A group(P<0.05).(4). Compared with the C group and B group, the A group had a lower level of fibrinogen levels(P<0.05). Conclusion:1. The SH group had a higher level of the morbidity of CHD than the normal thyroid function group.2. The SH group had a higher level of TC than the normal thyroid function group.3. In the CHD with SH group, the TSH level is higher, the Gensini score is higher and coronary artery lesions in the range, the greater the degree of stenosis is heavier.