Correlation Between Blood Lipid And Whole Blood Cell Count In Patients With Coronary Heart Disease

Objectives:To investigate whether there are gender and age differences in the composition of lipid-based risk factors and whole blood count-based risk factors in patients with coronary heart disease(CHD),and whether there is a correlation between lipid and whole blood count-based indicators and whether this correlation is gender and age specific.Methods:A total of 11,180 patients with CHD diagnosed in the cardiology department of our hospital were selected as the CHD group,including 6963 males(66.41±13.54)and 4217 females(70.18±11.63),and a total of 27,395 patients with health checkups were selected for the same period,including 17,196 males(46.28±12.16)and 10,199 females(43.43±11.67).The blood lipids were measured:total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LLDL-C),and triglyceride(TG).lipoprotein cholesterol(LDL-C),lipoprotein a(LP(a)),apolipoprotein A1(APOA1),and apolipoprotein B100(APOB100).Whole blood cells were measured:white blood cell(WBC),neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(MLR),and red blood cell(RBC).(red blood cell,RBC),platelet(PLT).1.All data were first tested for normality,and those that met the normal distribution continued to be analyzed using the original data,and those that met the normal distribution were log-transformed.2.Difference analysis was performed for males and females for each index tested,and the control and case groups were divided into five groups by age:<45 years,45-54 years,55-64 years,65-74 years,and≥75 years for intra-group comparison of each index.The variability in age distribution of the indicators was compared within groups.3.Trend graph analysis was performed for the change in lipid and complete blood count categories by age.4.The variability analysis of control and case groups was performed for each age group.5.The indicators with significant differences in each age group were included in the binary logistic regression analysis.6.Pearson correlation analysis.7.Trend plot analysis was done on r values obtained from Pearson correlation analysis for each age group.Results:1.In the normality test,we performed K-S test and P-P detrended plot analysis.In the P-P detrended plot,TC,HDL-C,LDL-C,APOA1,APOB100,RBC,and PLT basically conformed to the normal distribution and continued to use the original data.TG,LP(a),WBC,NLR,and MLR did not conform to the normal distribution and used the log-transformed data for subsequent analysis.2.We analyzed the control and CHD groups for differences in gender and age,and found that most of the lipid and complete blood count categories had differences in gender and age.3.The results of trend plots of lipid and complete blood count categories by age change revealed that:(1)lnTG,HDL-C,lnLP(a),lnMLR:the change trends were consistent between the control and CHD groups,the change trends of lnTG and HDL-C were inconsistent between males and females,and the change trends of lnLP(a)and lnMLR were consistent between males and females.(2)TC,LDL-C,APOB100:the change trends were not consistent between men in the control group and men in the CHD group,and the change trends were consistent between women in the control group and women in the CHD group.(3)APOA1,WBC,lnNLR,RBC,PLT:the change trends were different between control group and CHD group,and the change trends were inconsistent between males and females in APOA1,WBC,and consistent between males and females in lnNLR,RBC,and PLT.4.The results of the difference analysis between the control and CHD groups at each age found that most of the indicators differed between the case and control groups.5.Logistic regression revealed that the common risk factors for the occurrence of CHD in both males and females at all ages were:APOA1,lnLP(a),lnNLR,lnMLR,and RBC,and the risk factors that differed for the occurrence of CHD in both males and females at all ages were lnTG,HDL-C,and PLT.6.Pearson correlation analysis of common lipid-based risk factors with common complete blood count-based risk factors in males and females,respectively,revealed that APOA1 correlated with lnNLR,lnMLR,and RBC in both males and females,lnLP(a)correlated with lnMLR in males,lnLP(a)correlated with lnNLR and RBC in males correlation was weak,and lnLP(a)correlated weakly with lnNLR,lnMLR,and RBC in females.7.Trend plots of the correlation coefficients r values for common lipid-based risk factors and common complete blood count-based risk factors for men and women,respectively,revealed that:the absolute value of APOA1 correlation coefficient r with lnNLR,lnMLR,and RBC gradually increased with age in both males and females,the absolute value of lnLP(a)correlation coefficient r with lnMLR gradually increased with age in males and gradually decreased after 65 years of age,the absolute value of lnLP(a)correlation coefficient r with lnNLR,RBC gradually increased with age in both males The absolute values of lnLP(a)and lnNLR correlation coefficients r varied less among women,and the absolute values of lnLP(a)and lnMLR and RBC all gradually increased with age.Conclusions:1.There were gender and age differences in the composition of risk factors for lipids and complete blood count categories in patients with CHD.2.There was a correlation between lipids and complete blood count category as risk factors for CHD,and this correlation differed by gender and age.