Comparison Of The Effects Of Oxycodone And Fentanyl On The Recovery Period After Thoracic Surgery

Objective:Compare the differences between a single dose of oxycodone and fentanyl which is injected to the patients with thoracic surgery for acute postoperative pain and the quality of awakening.Methods:60patients, ASA I-II, 46 males and 14 females, BMI 22-26kg/m2,scheduled for thoracic surgery were randomly divided into two groups:oxycodone hydrochloride injection group(Q group n=30) and fentanyl injection group(F group n=30). Oxycodone 0.1mg/kg(saline dilution of1mg/ml) or fentanyl 1ug/ml(saline dilution of 10ug/ml)was injected intravenously at 20 min before the end of surgery. Extubating the tracheal when the patients were well awake: the circulation is stable, the breathing is smooth and the reflex activity recover. Cumulative the anesthesia duration, operation duration, extubation time and recovery time. The following data were recorded: HR and mean arterial pressure at the end of operation, extubation and 5min, 10 min after extubation. VAS postoperative pain scores and The Ramsay sedation scale, Side-effects such as dysphoria,nausea,vomiting, itch of skin, respiratory depression were also Measured.Results:The difference between the two groups of the extubation time and recovery time was not statistically significant. Repeated measures analysis of variance showed: the heart rate and mean arterial blood pressure trends of two group is consistent during the ending of surgery to a period of 10 minutes after extubation. The rate of postoperative acute pain of both group had eased, but the NRS scores of F group were higher than Q group, there is statistically significant difference(p<0.05). There was no significant difference between the two groups on the Ramsey sedation scale. The patients in both groups showed similar sedation levels.There was no significant difference in PONV, Side-effects such as dysphoria,itch of skin and respiratory depression in the oxycodone group were less than those in the fentanyl group, there is statistically significant difference(p<0.05).Conclusion:Oxycodone is secure used in the recovery period of general anesthesia. A single intravenous injection of oxycodone 0.1mg/kg is better than fentanyl 1ug/kg to prevent the acute postoperative pain after thoracic surgery at 20 min before the end of surgery.