Zhizhu Ginseng Ginger For Sotmach Deficiency Type Gastric Ulcer Role Model And Mechanism

Objective:This study is to observe the effect Zhizhu ginger Ginseng spleen and stomach ulcer in rats and to explore its mechanism of action, expecting further development of the party preparations foundation.Methods:The method of ice vinegar, acetic acid smear method to copy the spleen and stomach ulcer rat model, observe the effect of Ginseng zhizhu ginger rat spleen and stomach ulcer general physiological conditions, the morphology of gastric ulcer area inhibition, and observation of the stomach tissue superoxide dismutase (SOD) activity and malondialdehyde (MDA) content and serum nitric oxide (NO) content change.Results:1. Zhizhu ginger Ginseng can reduce the area of the spleen and stomach ulcer in rats (compared with the model group, p<0.01);.2 Zhizhu Ginger Ginseng can spleen and stomach ulcer rat gastric tissue SOD content increase (compared with the model group, p<0.01), MDA decreased (compared with the model group, p<0.01);.3 Zhizhu ginger Ginseng high dose can be increased spleen Deficiency type Gastric ulcer rats NO content (compared with the model group, p <0.01);.4 rat spleen and stomach ulcer gastric histopathological observation, compared with the model group, Zhizhu Ginseng ginger group to reduce stomach telangiectasia, neutrophils and lymphocyte infiltration reduction.Conclusions:1 Zhizhu Ginger Ginseng has anti spleen Deficiency type gastric ulcer;2 mechanism Zhizhu ginger Ginseng anti-gastric ulcer stomach Deficiency may by promoting the synthesis and release of gastric mucosal protective factor.enhance the gastric mucosal defense capability by increasing the gastric mucosal anti-free radical oxidation, reduce gastric mucosal damage and promote repair of gastric mucosa.