Relationship Between Serum Uric Acid And Cardiovascular Disease Risk Factors: Northern Shanghai Study

Objective: To investigate the relationship between uric acid with cardiovascular disease and its risk factors and target organ damage in northern Shanghai population; the purpose is to evaluate the association between serum uric acid with Metabolic Syndrome and its component; Then the study is to investigate the prevalence of hyperuricemia and its linking factors in northern shanghai individual.Methods: A cross-sectional survey was performed in 10 northern shanghai local communities and 1599 individual(aged ≥65 years) with based information was recruited. Standardized questionnaire was collected the individual information. Indicators of serum uric acid(SUA), height, weight, systolic blood pressure(SBP), diastolic blood pressure(DBP), smoking status, alcohol consumption, blood glucose, cholesterol, triglycerides,pulse wave velocity, ankle brachial index, glomerular filtration rate were collected. T test, one-way analysis of variance, Pearson’s correlation, multivariate linear regression, and multivariate logistic regression were used. SPSS 13.0 software was used to analysis the relationship between plasma uric acid and cardiovascular disease and its risk factors, target organ damage,Metabolic Syndrome, and the prevalence of hyperuricemia.Results: 1. The 1570 study participants included men(n=704),compared with women(n=866), had significantly(p<0.05) higher serum uric acid concentration(men vs. women 370.8±86.2 VS. 313.0±73.8 μmol/L, p<0.05), diastolic blood pressure(DBP), smoking status, alcohol consumption and intima media thickness(p<0.05).2. Correlation analysis demonstrated that serum uric acid was significantly and positively associated with age(r=0.12;p=0.001),SBP(r=0.13;p<0.001),body mass index(r=0.19;p<0.001),pulse pressure(r=0.11;p=0.002), triglyceride(r=0.27;p<0.001)in women. serum uric acid was significantly and negatively correlation with glucose(r=-0.12;p=0.001), high density lipoprotein(r=-0.19;p<0.001).3. Multiple linear regression analysis showed that serum uric acid had strong association with aged(β±SE =1.98±0.34 years;p<0.001),body mass index(BMI)( β±SE =3.44±0.63 kg/m2; p<0.001), HDL( β±SE =-55.7±5.86μmol/L;p<0.001)in all subjects.4. Multiple logistics regression analysis demonstrated that serum uric acid was significantly associated with target organ damage such as vascular damage, heart damage and renal damage. While divided the subjects into two groups, compared with lower group, the OR and its 95 CI was 1.37( odds ratio[OR]=1.37,95 CI 1.05-1.78;p<0.05)in pulse wave velocity,the OR and its 95 CI was 1.44(OR=1.44,95 CI 1.01-2.04;p<0.05) in ankle brachial index group, the OR and its 95 CI was 2.99(OR=2.99,95 CI 2.03-4.42;p<0.05)in glomerular filtration rate group.5. The prevalence of MS was 65.2%, 59.7% for man and 65.2% for women, respectively(p<0.05).The prevalence of MS increased with serum uric acid concentration,the two groups had significantly different.6. After adjustment for aged, gender, an increase of 1 μmol/L was associated with prevalence of MS(OR=4.61,95CI:3.33-6.38).7. The prevalence of hyperuricemia was 23.1%, 23.7% for man and 22.6% for women, respectively(p<0.001). The two groups had significantly different.8. The prevalence of hyperuricemia had significant difference in all subjects,men and women, and the female individual of hyperuricemia prevalence increased with increasing age(p<0.001).Conclusion: Serum uric acid was significantly correlation with cardiovascular disease risk factors(aged, body mass index) and target organ damage(pulse wave velocity, intima media thickness, left ventricular index, glomerular filtration rate). With the increase of the level of plasma uric acid, the risk index of the prevalence of cardiovascular disease and Metabolic Syndrome increased significantly. Uric acid significantly was relationship with Metabolic Syndrome and its components such as glucose, blood pressure and dyslipidemia. Aged, cholesterol, blood pressure and obesity were associated with increased risk of hyperuricemia. Compare with increasing aged in female, the increasing prevalence of hyperuricemia could be seen.