Expression And Significance Of Stathmin In Pancreatic Cancer

Background and Objective:Pancreatic cancer is obscure in onset and progresses rapidly with very poor prognosis, and it is urgent to find an ideal tumor marker of pancreatic cancer. Stathmin is a tumor marker, has been expressed in many tumor cells, but few study in pancreatic cancer. Here, we discuss the relationship between the clinicopathological features and expression of Stathmin in pancreaticcancer,and lay the foundation for the study of the relationship between Stathmin and pancreatic cancer, and then develop a new clinical therapy for pancreatic cancer.Methods:40 specimens with pancreatic cancer in Anhui Provincial Hospital from April 2009 to May 2014 were confirmed histopathology,27 adjacent normal samples of pancreatic cancer histologically confirmed as control group. Expression of Stathmin and Stathmin mRNA were detected in 40 pancreatic cancer samples,27 adjacent normal samples of pancreatic cancer respectively by immunohistochemistry and in situ hybridization.Results:Stathmin positive rate in pancreatic cancer tissues was significantly higher than adjacent normal pancreatic tissue (77.5% vs7.4%), the difference was statistically significant (P<0.05); the positive rate Stathmin mRNA expression was significantly higher than in adjacent normal organizations (80.0% vs7.4%), the difference was statistically significant (P<0.05). Different degree of differentiation, lymph node metastasis, distant metastasis and TNM staging Stathmin expression differences of pancreatic cancer organization were statistically significant (P<0.05).Conclusions:High level expression of Stathmin and mRNA in pancreatic tissue, and differentiation of pancreatic cancer, lymph node metastasis, distant metastasis and TNM staging closely related, suggesting Stathmin may be involved in pancreatic cancer development,Stathmin for early diagnosis and prognosis of pancreatic cancer judgment is important.