Clinical Study Of Suanzaoren Decoction To Improve The Rheumatoid Arthritis Patients With Anxiety And Depression

ObjectiveThis study is based on the comprehensive arrangement previously reported in the literature and clinical research findings, to study the anxiety and depression status of rheumatoid arthritis, to observe the use of Suanzaoren Decoction in the treatment of combined therapy with Deanxit combined foundation of two groups of patients, were used to evaluate their clinical efficacy, and the comparison between the two groups, to investigate the clinical efficacy and safety of Chinese medicine in the treatment of rheumatoid arthritis patients with anxiety and depression. MethodsIn accordance with unified diagnostic criteria and inclusion criteria, we collected 60 cases from The First Affiliated hospital of Guangzhou University of Chinese Medicine rheumatology clinic and ward. According to the grouping method of simple random, divided them into treatment group of 30 patients, control group of 30 patients. Treatment group given Suanzaoren Decoction combined with basic treatment:fried semen Ziziphi Spinosae 30g,5g of Ligusticum chuanxiong Hort, Zhimu 10g, Poria 30g, Caulis Polygoni Multiflori 30g, polygala root 10g, Radix 15g, Gancao 6g. One dose per day. Leflunomide tablets 20mg orally, once a day; in control group were treated with Deanxit combined with basic treatment:deanxit tablets 10.5mg oral, twice a day, leflunomide tablets 20mg orally, once a day. The treatment period was 4 weeks. In before and after treatment record the TCM clinical efficacy evaluation, SAS and SDS quantity table score, security index detection (including WBC, HGB, PLT, AST, alt, bun, Cr) and record adverse reactions, according to the indexes were observed before and after treatment, the patients in the two groups change collected research data, after finishing, establish a database, and statistical analysis was performed using SPSS 22.0, evaluate the clinical efficacy and safety of two groups. ResultsThere were no significant differences in clinical data of two groups of patients before treatment, such as gender, age, course of disease, RA stage, RA function classification, anxiety score and depression score, all of which were comparable (P>0.05). After 4 weeks treatment, the two groups of patients with traditional Chinese medicine clinical curative effect evaluation, by Ridit test analysis, u=2.094, P=0.036<0.05, prompt two groups of curative effect comparison has statistics difference. After 4 weeks of treatment, the treatment group of patients before and after treatment anxiety score group compared by t-test, t=11.584, P=0.0000##, suggesting that treatment anxiety scores before and after treatment in the case group have significant difference; control anxiety scores before and after treatment in the case group group compared by t-test, t=11.352, P=0.0000##, prompt control between anxiety scores before and after treatment in the case group with significant difference; two groups of patients before and after treatment anxiety score difference between groups compared by t-test, t=2.703,P=0.009<0.05*, suggesting that between the difference in the two groups of patients before and after treatment with statistically significant difference. Treatment group of patients before and after treatment depression score group compared by t-test, t=11.307, P=0.0000##, suggesting that treatment depression scores before and after treatment in the case group have significant difference; the control groups of patients before and after depression score group in comparison, by t test. t=11.618, P= 0.0000##, prompt control between depression score before and after treatment of patients with significant difference; two groups before and after treatment were depression score difference between groups comparison, by t test. t=2.347,P=0.022<0.05*, tips between the difference in the two groups of patients before and after treatment with a statistically significant difference. (Note:* indicates the comparison between groups, P< 0.05;## said the group before and after treatment were compared, P＜0.0.01). The above data show that treatment of the two groups of abnormal mental status of patients with rheumatoid arthritis were certain improving effect, but Suanzaoren Decoction on anxiety and depression scores of the degree of improvement was higher than that of the latter is more obvious. Two groups of patients were recorded before and after the treatment, the security index changes (including blood routine, liver and kidney function, using a paired t test, P value> 0.05, no statistically significant, indicating that the two groups of patients before and after the safety index changes had no significant difference. ConclusionSuanzaoren Decoction and Western medicine Deanxit can improve the anxiety and depression status of patients with rheumatoid arthritis in a certain extent, but data represent that, Suanzaoren Decoction can significantly improve the scores of SDS and SAS score degree, higher than that of the latter, especially the SAS score. No abnormal safety index to observe the change of Suanzaoren Decoction before and after treatment, and no obvious adverse events. In conclusion, this treatment has good safety, less adverse reaction, high treatment efficiency, is worthy of further promotion in clinical application.