Clinical Research On Efficacy Of Close Needling To Blood Serum IL-1β And TNF-α Of Cervical Spondylosis Radiculopathy Patient

Objective:Based on theoretical research and clinical observation about application of close needling to treat Cervical Spondylosis Radiculopathy (CSR), this research is aimed to discuss the function and functioning mechanism of inflammatory cytokines IL-1β and TNF-a in the occurrence and development of CSR clinical symptoms, observe the clinical effect of close needling in treating CSR, analyze the relation between clinical effect and inflammatory cytokines including blood serum IL-1β and TNF-α and their efficacy, and formulate concrete operating steps and some technical parameters for close needling to be widely used in clinical treatment so as to offer scientific methods to treat CSR and determine related effects.Methods:Function efficiency of close needling to blood serum inflammatory cytokines of CSR patients will be elaborated from two aspects, including theoretical research and clinical research. As to theoretical research, related documents and materials will be gathered by looking up books in libraries and searching database on CNKI. Starting from the appreciation of domestic and foreign doctors and scholars in ancient and modern times for CSR and focusing on modern research of occurrence and development process of CSR, this article will conduct an in-depth exploration and discuss the pathogenesis, sum up in a systematic way common traditional Chinese and western medical methods used to treat CSR in recent years, and at the same time, introduce the functioning principle of CSR and its clinical application at present. For clinical research, treatment group and comparison group will be set in a totally random manner so as to conduct related study. The treatment group will be comprised by 33 examples using close needling, while the comparison group will be made up by 31 examples using general needling in treatment. Patients in both groups will be treated once every other day and three times one week, with four weeks being one course of treatment. After two successive courses of treatment, a comparison will be made between the two groups on the concentration of blood serum IL-1β and TNF-α, visual analog scales (VAS), neck disability index (NDI) and 36-item short-form health survey (SF-36). As a result, the curative effect will be evaluated.Results:① After treatment, it is discovered that VAS and NDI of both groups were enormously lower than before (P<0.01). Moreover, VAS and NDI of the treatment group were obviously lower compared to those of the comparison group (P<0.05).② The eight dimensions of SF-36 of both groups, including Physical Functioning (PF), Role-Physical (RP), Bodily Pain (BP), General Health (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE) and Mental Health (MH), were all significantly improved after treatment than before (P<0.05). Among them, BP and SF of the treatment group were apparently better than the comparison group (P<0.05). And there is no statistical difference between the two groups in terms of the other six dimensions (P>0.05).③ The blood serum IL-1β and TNF-α of 64 CSR patients were obviously higher than that of healthy adults (P<0.01).④ The concentration of blood serum IL-1β and TNF-α of patients in both groups were obviously decreased through treatment (P<0.01). And the concentration of the treatment group is dramatically lower than the comparison group (P<0.05).⑤ The total efficiency of the treatment group is 90.9% while the efficiency of the comparison group is 80.6%. The difference is meaningful from the statistical perspective (P<0.05).⑥ NDI of CSR patients is positively correlated with concentration of blood serum IL-1β and TNF-α before and after treatment (P<0.05).Conclusion:① Occurrence and development of CSR is closely related to inflammatory cytokines IL-1β and TNF-α. One of the functioning mechanisms is that cytokines including IL-1β and TNF-α took part in the inflammatory reaction process of CSR.② Severity of illness is related to the concentration of IL-1βand TNF-α. The higher the concentration is, the more severe the disease is. This means that inflammatory cytokines are one of the major reasons for aggravation of CSR clinical symptoms.③ Close needling can obviously alleviate the clinical symptoms of patients and can produce good clinical effects by enormously cutting down the concentration of blood serum IL-1β and TNF-α of patients. Clinical effects are related to inflammatory cytokines.④ Close needling can be adopted as one of the common treatment methods for CSR and should be promoted to CSR patients and clinical doctors on the frontline.