Comparative Analysis On Diabetic With Early Renal Damage In Several Laboratory Index

Objective:This study was to compare the clinical application value of the four indexes of serum cystatin C(Cys), serum creatinine(SCR) and blood urea nitrogen(BUN) and urine beta 2-microglobulin(2-mg) in early diabetic renal function injury diagnosis and to investigate the relationship between serum cystatin C, serum creatinine, urea nitrogen and urine beta 2-microglobulin in diabetic early renal function injury diagnosis clinical application value. Methods:Tianjin Jinnan District xianshuigu hospital in 2009 January to December 2012 197 cases of clinically diagnosed type 2 diabetic patients as the research object, according to the glomerular filtration rate(GFR) were divided into three groups: normal renal function group(GFR>80ml/min), and 56 cases, 35 cases were male, 21 female patients, aged 45-63 years average 53.3 + 5.3 years chosen. Kidney function not compensatory group(50ml/min≤GFR≤80ml/min)89 cases, male 53 cases, 36 cases of female, old age 47~65, average 55.8 + 5.9 years old. The renal function was not complete loss compensation group(GFR<50ml/min) 52 cases, male 32 cases, female 20 cases, aged 47~68 years old, average 56.1 + 6.2 years old. The normal physical examination personnel 68 cases as the control group, male 40 cases, female 28 cases, aged 41~63 years old, average 54.2 5.5 years old, each group sex, age constitute no significant difference with comparability. The Cys-C, Scr, BUN and urinary 2-MG were detected, and the diagnosis of Cys-C, BUN, Scr and urine beta 2-MG in early diabetic renal damage were observed. Results:Renal function damage of renal disease of urinary sugar insensitive but Cys-C, urinary beta-2-microglobulin concentration(1.84 + 0.68 mg / L, 2.62 + 1.17 mg / L) and abnormal rate(82.0% and 76.4%) were in diabetic renal insufficiency compensatory group increased, and 56 cases set with diabetes renal function in normal group and selected 68 cases of normal control group were compared with statistical difference(P < 0.05), early in the bun, SCR, serum cystatin C and urinary B2-MG has good sensitivity and Youden index, coincidence rate and negative predictive value, bun and SCR in diabetic renal insufficiency compensatory stage of early diabetic renal damage misdiagnosis rate is high, but in the late two indicators can be more correct responses. Conclusions:Improvement in patients with early diabetic renal damage as a common diabetic chronic complication of, a serious threat to the patient’s life. Early diagnosis and control of early diabetic renal damage, can be very good, on the condition of stability control, so as to improve the clinical significance. BUN and Scr are not suitable for the diagnosis of renal damage in early stage of diabetes.. Cys-C and 2- M G h a v e g o o d c l i n i c a l v a l u e f o r t h e d i a g n o s i s o f e a r l y renal damage to diabetes.