Effect Of Vitamin D On Postprandial Hyperglycemia Inflammatory Factors In Patients With Hypertensive

Background:Diabetes mellitus(DM) is a chronic non communicable disease, and is a major public health problem facing the whole mankind at present. International Diabetes Federation reported that the number of people with diabetes in the world is more than 300 million, and is expected to reach 550 million in 2030. The prevalence of DM and prediabetes in China is rising at an alarming rate. The Chronic Non communicable Disease surveillance displayed, the number of DM patients in China has reached 93 million. To 2010, the prevalence of adult diabetes in China has increased to 11.6%, and the prevalence of prediabetes has been estimated 50.1%. Continuous increasing in the population of diabetes patients further increase the burden on the health care system in our country. Therefore, the prevention and treatment of diabetes is of no delay.The major cause of disability and death in patients with DM is the vascular complications, and Cardio vascular complications are the main cause of death in patients with diabetes. Hypertension is one of the major vascular complications of DM and it is also one of the main causes of death. In recent years, the incidence of DM complications with hypertension showed a significant upward trend, so further research and explore its pathogenesis and find new therapeutic methods have important theoretical and practical significance.Objective:To investigate the levels of blood sugar, blood pressure, vitamin D, inflammatory factors in hypertensive patients with impaired glucose tolerance and intervention effect of vitamin D. To observe the correlation between vitamin D and blood pressure, blood sugar,inflammatory factor.Methods:Choose 148 cases of elderly Patients,according to whether with Impaired glucose tolerance and systolic hypertension of level 1, 69 patients are divided into high blood pressure group, 30 patients with Impaired glucose tolerance, 49 patients with high blood glucose levels are divided into Impaired glucose tolerance groups.Choose 50 cases of the same period the healthy check-up as control group.Hs-CRP, TNF-α and 25-(OH)D3 were measured. 49 Patients with high blood glucose were given Vitamin D 800 Iu, qd. After 12 weeks treatment, three serum levels were detected and compared.Results:The levels of 25-(OH)D3 in hypertension group and with high blood glucose group were lower than control group; 25-(OH)D3 levels in hypertension with high blood glucose group were lower than hypertension group; The levels of hs-CRP, TNF-α in hypertension group and hypertension with high blood glucose group were higher than control group; The levels of hs-CRP, TNF-α in hypertension with high blood glucose group were higher than hypertension group. 25-(OH)D3 and blood pressure, 2-hour postprandial blood glucose were negetively correlated, hs-CRP, TNF-α and blood pressure, 2-hour postprandial blood glucose were positively correlated. After vitamin D treatment, the levels of hs-CRP, TNF-α were declined obviously(P<0.05).Conclusion:1. The levels of 25-(OH)D3 in hypertension group and with IGT group were lower than the control group, the levels of hs-CRP and TNF-α were higher than the control group, suggesting that the presence of vascular wall inflammation in patients with hypertension and inflammatory reaction may be involved in some pathophysiological process of hypertension.2. The levels of 25-(OH)D3 in hypertension with high blood glucose group were lower than the control group and prehypertension group, the levels of hs-CRP and TNF-αwere higher, suggesting that the levels of hs-CRP and TNF-α were not only related to the blood pressure, but also to 2h PBG.3. The levels of 25-(OH)D3 in the IGT group were lower than the control group, the levels of hs-CRP and TNF-α were higher than the control group, suggesting that the patients with IGT may be due to oxidative stress, endothelial injury or other reasons,there is a certain inflammatory response. The inflammatory reaction correlated with postprandial hyperglycemia.4. No clinical events occurred during the 12 weeks of the study, research results show that patients with hypertension with IGT group and the IGT group were given Vitamin D 800 Iu, qd po, after 12 weeks, the levels of 25-(OH)D3 were increase, CRP and TNF-α were decline sharply, this may be related to the concentration improvement of Vitamin D.Inflammatory factor levels of hypertensive patients with postprandial hyperglycemia were higher than pure hypertensive patients, inflammatory reactions is more obvious.Vitamin D may reduce the inflammation.