Randomized Controlled Studay Of Tongnao Fang On Phlegm And Blood Stasis Type Of Cerebral Arteriosclerosis

Objective: Through the observation of the effect of traditional Chinese medicine syndrome, homocysteine, blood lipid and TCD in patients with phlegm and blood stasis syndrome, we investigate the clinical efficacy and safety of Tongnao Fang in the treatment of phlegm and blood stasis syndrome to provide theoretical support for scientific and rational guidance of clinical medication.Method: Cases were collected form old TCM Hospital of Gansu Province Department of inpatient department from September 2014 to December 2015.60 patients with cerebral arteriosclerosis was selected to meet the criteria of this study.They were randomly divided into treatment group and control group with 30 cases in each group.Treatment group were treated with Tongnao Fang,On the basis of routine western medicine treatment,Control group were treated with Naoxintong capsule. 4 weeks for a course of treatment were observed before and after treatment in patients with TCM syndrome score, homocysteine, lipids,transcranial Doppler(TCD) and evaluate the effect and safety of the two groups.Results:1. Comparison of score in two groups of patients with TCM syndrome:the treatment group had statistical difference(P<0.05) in the improvement of individual symptoms. The differences between the two groups were significantly improved in the aspects of syndrome total score(P<0.05), indicating that the treatment group is better than the control group.2. Comparison of curative effect of the two groups with syndrome: the total effective rate of treatment group was 93.3%. In the control group, the total effective rate was 73.3%. Two groups of patients in the improvement of therapeutic effect of syndrome both had statistical difference(P<0.05), indicating that the treatment group was significantly better than the control group.3. Comparison of Hcy effects in two groups : After treatment the level of Hcy in the treatment group was significantly lower than that in the control group. The two groups in the improvement of Hcy both had statistical differences(P<0.05), indicating that the treatment group was better than the control group.4. Comparison of serum lipids in the two groups: After treatment, comparing the treatment group and control group, the levels of TG,TC and LDL-C were decreased,HDL-C levels were elevated,and the statistical differences(P<0.05),were found in the level of TG and HDL-C.The camparison of TC, TG, LDL-Cand HDL-C in each groups had no statisticaldifference(P>0.05).5. Comparison of TCD effects in two groups after treatment: Comparing the two groups,the, Vm(cm/s) on the right side, in the treatment group were increased in different degrees. PI values were significantly decreased. There had statistical differences between the two groups in the improvement of partial Vm and PI(P<0.05), indicating that the treatment group was significantly better than the control group.Conclusion: Through the study of the effect of Tongnao Fang on the cerebral arterial stiffness of phlegm and blood stasis, it can effectively improve the patient’s clinical symptoms,the same type of cysteine. It also can be effective in the Doppler flow velocity at the same time. It has nearly the same effect in improving blood lipid with clinical efficacy of Naoxintong. It verifies the effectiveness and safety of Tongnao Fang in the treatment of phlegm and blood stasis mutual knot type of cerebral arteriosclerosis.