| Objective:This study was conducted to evaluate the effectiveness and safety of the method of removing phlegm and eliminating stasis in the treatment of hyperlipidemia with phlegm and stasis,by means of Meta-analysis,to provide evidence-based medical evidence for the future clinical treatment of hyperlipidemia.Methods:The Chinese databases:China Knowledge Network(CNKI),Wanfang Database(Wanfang Data),VIP D at abase(VIP),Chinese Medical Biological Literature Database(CBM),and English databases:PubMed,Embase,and The Cochrane Library were searched for the clinical treatment of phlegm-stasis hyperlipidemia by the method of resolving phlegm and dispelling stasis.Randomized controlled trials.The search was conducted from the time of database construction to September 2022.The useable literature was identified by the inclusion and exclusion criteria developed.Data extraction was performed on the literature,baseline,interventions,diagnostic criteria,and outcome indicators.The outcome data were analyzed using stata 16 software to create forest plots and publication bias analysis for clinical effectiveness.Results:A total of 17 papers,including 3 dissertations and 14 journal papers,were included according to the nadir criteria and searched by the search strategy.A total of 1530 patients were included in the study,798,cases in the treatment group and 732 cases in the control group.The outcome measures were analyzed,and the results were presented as follows:1.Clinical efficiency:RR=1.06,95%CI[1.01,1.11],P=0.012(P<0.05).The results were statistically significant,suggesting that the treatment group was better than the control group in terms of clinical efficiency;2.TCM symptom efficacy:RR=1.62,95%CI[1.23,2.13],P=0.001(P<0.01).The results were highly statistically significant,suggesting that the treatment group was significantly better than the control group in terms of TCM symptom efficacy;3.TC:SMD=-0.13,95%CI[-0.4 8,0.23],P=0.4 79(P>0.05).The resu Its were not statistically significant,suggesting that the two groups were comparable in terms of treatment effect in reducing TC levels;4.TG:SMD=-0.46,95%CI[-0.83,-0.09],P=0.016(P<0.05).The results were statistically significant,suggesting that the treatment group was superior to the control group in reducing TG levels;5.HDL-C:SMD=0.25,95%CI[-0.05,0.54],P=0.099(P>0.05).The results were not statistically significant,suggesting that the treatment effect was comparable between the two groups in lowering HDL-C levels;6.LDL-C:SMD=-0.17,95%CI[-0.54,0.19],P=0.355(P>0.05).The results were not statistically significant,suggesting comparable treatment effects in lowering LDL-C levels in the two groups;7.TCM symptom score:SMD=-1.17,95%CI[-1.57,-0.77],P=0.00(P<0.01).The result was highly significant statistically,suggesting that the treatment group was significantly better than the control group in terms of TCM symptom score;8.Adverse effects:SMD=0.11,95%CI[0.04,0.34],P=0.000(P<0.01).The results were highly statistically significant,suggesting that the treatment group was significantly better than the control group in terms of medication safety;9.Bias analysis:There is a possible risk of publication bias for clinical efficiency,TC,TG,and HDL-C,and no risk of publication bias for LDL-C;10.The frequency of drug use in the included literature wascounted,in which the frequency of occurrence was higher for Pinellia ternata,Danshen root,Crataegus,tangerine peel,Rhizoma alismatis,Poriacocos,Atractylodes macrocephala,Safflower,Peach Seed,and Red Peony Root.Conclusion:1.The treatment of phlegm-stasis hyperlipidemia was better than the control group in terms of clinical efficiency,TCM symptom efficiency,TCM symptom score,triglycerides,and medicati on safety indexes by the method of resolving phlegm and dispelling stasis.2.The treatment of phlegm-stasis hyperlipidemia with phleg m-stasis method did not differ significantly from the control group in improving TC,HDL-C and LDL-C levels. |
PDF Full Text Request