The Relationship Between The 8 Level And The Severity Of Coronary Artery Lesions In Patients With ACS Serum Homocysteine, Interleukin 6 And Interleukin

Objective:The detection of acute coronary comprehensive syndrome(ACS) in peripheral blood of patients with the same type of homocysteine(HCY), serum leukocyte mediated IL 6(IL-6) and leukocyte mediated element 8(IL-8) and with the number of diseased coronary artery relationship to find the relationship between the incidence of coronary heart disease and inflammatory mechanisms. Methods:Selection of Fenyang hospital, Shanxi Province, admitted to Department of Cardiology, coronary artery angiography in the diagnosis of patients with a total of 170 people, which acute coronary artery syndrome group(ACS, n = 97), stable angina pectoris group(SA)(n = 36) and non CHD group(NCHD, n = 37). Was measured by enzyme linked immunosorbent assay(ELISA) were detected in three groups of patients immediately after admission patients of plasma HCY, serum IL-6 and IL-8 levels; by coronary angiography to evaluate coronary lesion vessels. The relationship between the 8 level and coronary artery lesions of ACS patients’ serum homocysteine, interleukin 6 and interleukin. Results:1.Differences in age, sex ratio, hypertension, hyperlipidemia hyperlipidemia, smoking, diabetes, CHD family history, BMI between the three groups had no statistical significance(P>0.05) and selected biochemical parameters in patients with consistent with comparability.2.The HCY, serum IL-6 and IL-8 levels in patients with 2.ACS were significantly higher than those in group NCHD and group SA, but there was no significant difference in the three indexes between NCHD group and SA group.3.peripheral serum IL-8 levels were significantly higher than that of single vessel disease group(P<0.05) and double vessel disease group(P<0.05); there was no significant difference between the two groups(P<0.05) and single vessel lesion group. Peripheral plasma Hcy level three branch lesion group and double vessel lesion group were significantly higher than those of single vessel disease group(P<0.05), double vessel lesion group and three branch lesion group differences had no statistical significance; had no statistically significant difference in different lesion vessels, the serum level of IL-6.(P > 0.05). Conclusion:1, ACS group of patients with peripheral plasma HCY, serum IL-6 and IL-8 levels were significantly higher than that of patients with NCHD group and SA group, while the NCHD group and SA group of patients with peripheral blood between the three indicators have no statistically significant difference.There was statistical significance, 2 patients with ACS, IL-6 and IL-8 to compare the serum HCY levels and coronary lesions difference.3, peripheral serum IL-8 level of three lesions group was significantly higher than the single vessel disease group(P<0.05) and double vessel disease group(P<0.05); there was no significant difference between the two groups. Peripheral plasma HCY level three branch lesion group and double vessel lesion group were significantly higher than those of single vessel disease group(P < 0.05), double vessel lesion group and three branch lesion group differences non significant; different lesion vessels, the serum level of IL-6, the difference was not statistically significant(P > 0.05).