Visual Quality In Patients With Myopia

Objective: This study is on the basis of best corrected visual acuity（BCVA） in normal or even better in the patients with myopia. To investigate the differences of diopters, ocular axial length, intraocular pressure, central corneal thickness, wavefront aberrations in different visual acuity eyes. And to find if there is the area under the log contrast sensitivity function（AULCSF） differences between different visual acuity. Under different lighting conditions, to study the differences in contrast sensitivity（CS）, as well as to study the differences in ocular aberrations.To investigate the relationship between ocular aberrations and contrast sensitivity in myopia eyes.Method:（1） This is a retrospective study. By gathering the best corrected visual acuity、diopters of spherical refractive error、intraocular pressure、ocular axial length、centre corneal thickness、corneal aberrations、ocular aberrations、contrast sensitivity, to analysis the differences of indexes in different visual acuity eyes.（2） The Zemike aberrations、AULCSF was calculated to compare the differences in various lighting conditions.（3） All subjects divided into two groups based on the aberration by mean value,the distribution of CS were respectively inspected in two groups,and the differences among two groups were compared.As while, all subjects divided into two groups based on the CS by mean value,the distribution of ocular aberrations were respectively inspected in two groups,and the differences among two groups were compared. Using multiple stepwise regression method to study the relationship between ocular aberrations and contrast sensitivity（4 spatial frequency and AULCSF） in myopia eyes.Result:1. The results of spherical equivalent, axis oculi, noncontract tonometer, central corneal thickness were all of no statistical significance in BCVA 1.0 group and BCVA 2.0 group. With corneal and ocular aberrations, SAll RMS,Sh, Scoma, STrefoil, SSph,, Z₃³ã€Z₃^-3 、Z₃^-1、Z₃¹ under 4mm pupil diameter as index, after the statistical analysis between the BCVA1.0 group and the BCVA2.0 group, the difference was found of no statistical significance. The AULCSF values of group BCVA 1.0 and group BCVA 1.2 under light condition were respectively 1.26±0.11 、 1.32±0.10, and the difference was of statistical significance. The AULCSF values of group BCVA 1.0 and group BCVA 1.2 were respectively 1.26±0.12、1.30±0.12, and the difference was of statistical significance. The difference of AULCSF values under dark glare condition was of no statistical significance.2. In comparison between the dark glare condition and the light condition, the differences of SAll RMS, Sh, Scoma, STrefoil were all of statistical significance, and the differences of SSph,、Z₃³ã€Z₃^-3、Z₃^-1、Z₃¹ were of no statistical significance. In comparison between the dark glare condition and the dark condition, the differences of all aberrations were of statistical significance. In comparison between the light condition and the dark condition, the differences of all aberrations were of statistical significance. And the aberrations increased as the pupil diameter increased. In comparison between the light condition and the dark condition, the 3c/d frequency was of statistical significance, and the differences of 6c/d、12c/d、18c/d、AULCSF were of no statistical significance. In comparison between the light and the dark glare condition, and between the dark and the dark glare condition, the differences of 3c/d、6c/d、12c/d、AULCSF were of statistical significance（P<0.05）, and the difference of 18c/d frequency was of no statistical significance（P>0.05）. In the light and the dark condition, the contrast sensitivity was better than that in the glare condition, and the contrast sensitivities under above three conditions were found of no difference only under high frequency.3. When the BCVA was 1.2, the group in which the AULCSF was below the mean value,the SAll RMS 、spherical equivalents are better than the group in which the AULCSF was above the mean value under light condition. In comparison between the group in which the AULCSF was below the mean value,Sh 、SSph are better than the group in which the AULCSF was above the mean value under dark condition. When the BCVA was 1.0, the group in which the AULCSF was below the mean value,the Sh、STrefoil are better than the group in which the AULCSF was above the mean value under light condition. In comparison between the group in which the AULCSF was below the mean value,SSph are better than the group in which the AULCSF was above the mean value under dark condition.4.When the BCVA was 1.2, the group in which SALL RMS was below the mean value,the AULCSF is better than the group in which SALL RMS was above the mean value under light condition. The group in which SSph was below the mean value,the AULCSF is better than the group in which SSph was above the mean value under dark condition,as well as dark glare condition. When the BCVA was 1.0, the group in which Sh, Scoma, STrefoil was below the mean value,the AULCSF is better than the group in which Sh, Scoma, STrefoil was above the mean value under light condition. The group in which SSph was below the mean value,the AULCSF is better than the group in which SSph was above the mean value under light condition,as well as dark condition.5.In the analysis of the contrast sensitivity and aberrations under different frequencies and illuminating conditions, it was found that the SAll RMS and spherical aberration under different frequencies and illuminating conditions were negatively correlated with visual quality, and that the vertical coma was positively correlated with visual quality.Conclusions:1. In comparison between BCVA 1.0 and BCVA 1.2 among people with myopia, no differences were found in their spherical equivalent, axis oculi, noncontract tonometer, central corneal thickness. Their corneal and ocular aberrations were of no difference, for visual formation is a complicated process, the repeatibility of aberration measurement is slightly lower, and there are compensation and superposition of light and its aberrations in the eyes, thus no significant difference was found in the visual aberrations between these two groups. By comparing areas under function curve of contrast sensitivity in different groups, it was found that the eye with better visual acuity had more function curve area than the eye with relatively poor visual acuity.2 After comparison of the contrast sensitivities under different illuminating conditions, it was found that the pupil diameter was relatively bigger, and the ocular aberrations were greater than that under the light condition and the dark glare condition. After comparison of the contrast sensitivities under three illuminating conditions,it was found that direct ray from the front may decrease the visual acuity, it causs blurred vision thus the visual quality decrease due to glare.3. Under light condition, when the BCVA was 1.2, the AULCSF was related to low order aberration; when the BCVA was 1.0, the AULCSF was related to high order aberration. Under dark condition, the negative influence of spherical aberration on visual quality was relatively bigger, while the influence of the other aberrations was not significant. For the direct ray under dark glare condition, the influence of aberrations on visual quality was not significant. In the analysis of the contrast sensitivities and aberrations under different frequencies and different illuminating conditions, the SAll RMS, spherical aberration in different conditions and different frequencies were negatively correlated with visual quality, and the vertical coma was positively correlated with visual quality.