The Correlative Of Traditional Chinese Medicine Syndromes With Cognitve Feature In PD And The Clinical Study Of Kangzheng Zhijing Capsule Treat PD-MCI With Blood Stasis And Wind Act

1 Objective The objective was to observe the linical cognitive function characteristics in Parkinson’s disease and to explore related risk factors,observe the TCM syndrome distribution characteristics and its correlation with cognition;Observe Kangzhen Zhijing Capsule on cognitive intervention effect of Parkinson’s disease,to explore its mechanism of action,Rich Chinese medicine treatment methods on cognitive impairment with Parkinson’s Disease.2 Methods(1)Use the Unified Parkinson’s Disease Rating Scale、Hoehn and Yahr Staging assess the PD patients’ clinical motor symptoms;use the Mini-Mental State Examination(MMSE)、Montreal Cognitive Assessment(Mo CA)、Stroop color-word test(SCWT)、Verbal Fluency Test(VFT)、Clock drawing test(CDT)、Auditory verbal learning test(AVLT) assess the PD patients’ cognitive behavioral characteristics;use therapeutic effect evaluation standard of TCM syndrome, blood stasis type pneumatic cognitive impairment in Parkinson’s disease of TCM syndrome score standard analysis of PD drug intervention effect;(2)Were included in the standard of 60 patients with PD syndrome under the cognitive function and assessment, selected 40 cases of blood stasis type dynamic wind PD-MCI patients were randomly divided into treatment group(20 cases) Chinese traditional medicine and western medicine control group(20 cases),traditional Chinese medicine group seismic antispasmodic capsule,western medicine group to be more nai pp qi, observe clinical efficacy of two groups of patients,Mo CA score, special cognitive domain score and TCM syndrome integral to change.3 Results(1)Of the 80 patients with PD, PDD 23 cases(28.75%), PD-MCI 47 cases (60.0%);In the field of comprehensive cognitive assessment of PDD group in the MMSE score, MMSE and instant recall, weak in PD and Mo CA and named three aspects- NC group, the PD-MCI group;Three groups in terms of Mo CA, five special cognitive domain evaluation difference;(2)PD patients with cognitive impairment involving cognitive domain to carry out executive dysfunction and attention damage is given priority to, the second is the memory damage and damage to visual space, the language barrier is lighter;(3)Syndromes and one of five special cognitive assessment for correlation analysis, the results showed that liver and kidney deficiency and attention, memory is closely related to, blood stasis pneumatic and executive function, space, language is closely related to, phlegm hot air and visual space, language is closely related to;(4)Multivariate classification Logistics regression analysis shows that the fixed number of year of the education and uric acid levels and negatively correlated with the onset of PD cognitive impairment, Hcy levels, HAMD, UPDRS- Ⅲ was positively correlated with the onset of PD cognitive impairment;(5)Before and after treatment, the traditional Chinese medicine and western medicine group can improve cognitive function in patients ADL scores and comprehensive scores, and Chinese medicine group after treatment in UPDRS-Ⅲ, H- Y scores improved significantly in the western medicine group;(6)Donepezil has PD-MCI patients’ visual space, improve memory and language three aspects, and the seismic antispasmodic capsule in three aspects, attention, executive function and visual space have improved, in terms of visual space, Chinese medicine group is better than that of many Donepezil.4 Conclusion(1)PD characteristics of cognitive impairment of executive function, visual space obstacle on subcortical cognitive impairment;In PD- MCI parting, in order to not forget a single damage is the most common cognitive domain;(2)PDD is given priority to with liver and kidney deficiency type;And PD-MCI is given priority to with blood stasis type pneumatic;Liver and kidney deficiency and attention, memory is closely related to, blood stasis pneumatic and executive function, space, language is closely related to;(3)Level of education and uric acid levels are PD independent protection factors of cognitive function;Onset age, duration, UPDRS-Ⅲ, Hcy, depression is PD a risk factor for cognitive impairment;(4)Seismic antispasmodic capsule and more pp qi can improve cognitive function in patients with PD-MCI and daily life ability;And seismic antispasmodic capsule can improve PD-MCI motor symptoms;Seismic antispasmodic capsules improve PD patients with MCI execution/attention, visual spatial ability is more obvious;While donnelly, pp together in order to improve the language with PD-MCI, memory, visual spatial ability, give priority to.