| Objective:Systemic lupus erythematosus(SLE) is a chronic, immune-mediated,inflammatory multi-system disease, the disease can affect blood vessels, causing multiple organ multi-systemic disease, Vascular damage itself is a manifestation of SLE. SLE vascular damage mainly by immune complex deposition in the vessel wall caused by a series initiated mediated activation of the complement cascade reaction,the disease pathological basis of vascular inflammation. Microcirculation(NCV)examination as a non-invasive screening method microvascular has become increasingly widely used in the assessment of microvascular disease in patients with systemic sclerosis, disease monitoring and assessment of efficacy in the international arena. Application of this technique in patients with systemic lupus erythematosus has made some progress, however, with regard to patients with systemic involvement of different organs and different disease states and the study of the relationship between microcirculation, domestic few reports, study abroad is also in its infancy stage, a relatively small study and no consistent conclusion. Eye Signs of Blood Stasis Syndrome is an objective and accurate judgment stasis syndrome severity approach. Professor Li first proposed new diagnostic signs of Blood,by observing the vascular changes bulbar conjunctiva microcirculation, reported injury point, hemangiomas, reticular abnormalities and skin and eye blood stasis syndrome and other indicators to judge the degree of severity. Blood Stasis eye disease bulbar conjunctiva microcirculation observation points is a method of the bulbar conjunctiva microcirculation field Niushi bulbar conjunctiva microcirculation integrated quantitative evaluation methods derived reference to blood stasis syndrome eye syndrome basis. In this study, a total of inquiry object divided into three parts. The first part is to explore the differences between SLE patients and healthy volunteers between the microcirculation. The second part is based on clinical symptoms of SLE, laboratory test positive or not a packet, exploration between positive and negative groups Microcirculation, differences stasis syndrome bulbarconjunctiva microcirculation of eye disease between. The third part is to explore the relationship of SLE patients Microcirculation between Eye Signs of Blood Stasis Syndrome bulbar conjunctiva microcirculation calculus, white blood cells(WBC),platelets(PLT), complement C3, complement C4,24 hour urinary protein, disease activity(SLEDAI) and erythrocyte sedimentation rate. Explore the microcirculation of laboratory tests to check whether the severity of SLE and somewhat suggestive.Methods: Select our department patients diagnosed with SLE, 80 cases and 20 healthy volunteers. Compare microcirculation difference between two groups,respectively. Then SLE 80 patients, respectively, according to the presence or absence between pulmonary fibrosis(ILD), the SLE patients were divided into groups with and without ILD group; According to the presence or absence of pulmonary hypertension(PAH), the SLE patients were divided into groups with and without PAH group; Divided according to whether the rash combinations SLE rash no rash group; According to the presence or absence of Raynaud’s phenomenon(RP),which is divided into groups and non-RP group; According to the presence of each antibody divided into positive and negative groups, Comparison between the two groups Microcirculation difference stasis syndrome eye syndrome bulbar conjunctiva microcirculation. Analysis the relationship of SLE patients Microcirculation between Eye Signs of Blood Stasis Syndrome bulbar conjunctiva microcirculation calculus, white blood cells(WBC), platelets(PLT), complement C3,complement C4,24 hour urinary protein, disease activity(SLEDAI) and erythrocyte sedimentation rate.Results: This study nailfold microcirculation in capillaries branching points,the number of capillaries, the capillaries expand, huge capillaries, micro-bleeding,loss of capillaries arranged integral rule project, SLE group points higher than the HC group, the difference was statistically significant( P <0.05); Eye Signs of Blood Stasis Syndrome bulbar conjunctiva microcirculation integral fresh bleeding,bleeding old, twisted blood vessels, vascular thickening, reticular abnormalities,hemangioma, hue integration project, SLE group points higher than the HC group,the difference was statistically significant( P <0.05), points in the newspaper injury in SLE group than in HC group, but not statistically significant(P> 0.05).In the SLE group Microcirculation Calculus, according to the clinical symptoms of the presence or absence of each antibody-positive or not the packet; In a rash group is greater than the number of capillaries integration without rash group,a significant differences(P <0.05). Raynaud’s phenomenon in the group have branched capillaries, capillary number of points greater than the group without Raynaud’s phenomenon, in ILD huge group of capillaries, capillary arrangement lose no more than the rules of the integral group of interstitial lung disease, in pulmonary hypertension group capillaries branch points greater than the expansion of capillaries without pulmonary hypertension group, in the anti-RNP antibody positive group is greater than the expansion of capillaries integral anti-RNP antibody-negative group,the difference was statistically significant(P <0.05).Stasis syndrome in SLE group head disease bulbar conjunctiva microcirculation in total score, according to various clinical symptoms of the presence or absence of each antibody-positive or not packet; in the group have Raynaud’s phenomenon,pulmonary hypertension group, anti-RNP antibody positive group total score greater than or asymptomatic antibody-negative group, the difference was statistically significant(P < 0.05).In the SLE group Microcirculation,between Eye Signs of Blood Stasis Syndrome bulbar conjunctiva microcirculation calculus, white blood cells(WBC),platelets(PLT), complement C3, complement C4,24 hour urinary protein, disease activity(SLEDAI) and erythrocyte sedimentation rate, there are no correlation between each other(P> 0.05).Conclusion: Microcirculation in patients with systemic lupus erythematosus,blood stasis syndrome eye syndrome bulbar conjunctiva microcirculation points higher than in healthy persons, description existence microcirculation in patients with systemic lupus erythematosus. In patients with systemic lupus erythematosus,Microcirculation examinations and whether rash, interstitial lung disease, pulmonary hypertension, anti-RNP antibody related; Microcirculation inspection of each specific project integrator may prompt various clinical symptoms. Blood Stasis eye disease bulbar conjunctiva microcirculation check whether indexes Raynaud’s phenomenon, pulmonary hypertension, anti-RNP antibodies. Eye Signs of BloodStasis Syndrome bulbar conjunctiva microcirculation examination of each specific project may prompt corresponding clinical symptoms or antibodies or not.Microcirculation in patients with SLE can check some of the clinical symptoms and organ involvement has some predict. |
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