Recombinant Human Tumor Necrosis Factor Receptor Type Ⅱ-IgG Fc Fusion Protein For Treatment Of Occupational Medicamentosa-Like Dermatitis Induced By Trichloroethylene

Objective To investigate the efficacy and safety of the recombinant human tumor necrosis factor receptor Ⅱ-Ig G Fc fusion protein(rh TNFR:Fc,etanercept)for the treatment of occupational medicamentosa-like dermatitis induced by trichloroethylene(OMDT).Methods 12 patients with OMDT were treated with etanercept(25 mg,subcutaneous injection,twice per week,doubling of first dose).The course of treatment was 6 weeks.The Drug Eruption Area And Severity Index(DASI)score,the proportion of patients achieving a 50%,75% and 90% reduction in DASI(DASI50,DASI75,DASI90)and the serum level of TNF-αwere used to assess the efficacy at different times.Adverse reactions were also recorded and evaluated.The results were statistically analyzed by nonparametric Friedman test and repetitive measurement ANOVA using the software SPSS19.0.Results After 4 weeks treatment,the DASI score decreased form 56.33±7.02 to 33.33±5.87(P<0.01).The DASI50,DASI75 and DASI90 were all increased to 12(100%).The serum level of TNF-α decreased form(43.74±41.62)pg/ml to(3.03±0.47)pg/ml(P<0.01).Statistically significant difference was observed from the above indexes.There were no adverse reactions in clinical application.Conclusion Recombinant human tumor necrosis factor receptor Ⅱ-Ig G Fc fusion protein is a safe and effective drug in the treatment of OMDT.