Study On The Risk Of Nonalcoholic Fatty Liver Disease And Community Intervention In Middle-aged Population In Urumqi

Objective: To analyze epidemic characteristics and dominant risk factors of community of nonalcoholic fatty liver disease(NAFLD),the study investigates the sickness prevalence of NAFLD among the middle-aged people of Urumqi City,and implements community intervention on the NAFLD patients,in order to alleviate the degree of fatty liver patients and promote patient’s overall health level,so as to provide the theoretical basis for the development of the disease prevention and intervention.Methods: With the community as a unit,through cluster sampling,questionnaire consultation,anthropometric measurements(height,weight,blood pressure,waist circumference,hip circumference,neck circumference,subcutaneous fat thickness),blood biochemical(including liver function,fasting blood glucose,uric acid)and abdominal ultrasound examination of liver to investigate the NAFLD sickness among middle-aged people in community,so as to analyze the main risk factors;and randomly divide the screened community-based NAFLD patients into intervention group and control group to carry out community intervention,explore scientific intervention methods,in order to achieve early discovery and two levels of prevention and early treatment,thus reduce the cost of medical care,promote health of people.Results: 1.Among 844 middle-aged people in Xinjiang community of Urumqi city,detected NAFLD patients were 456 and morbidity rate was 54.03%;2.The morbidity rate of NAFLD in Uygur and Han were64.71% and 48.66%.Morbidity rate of Uygur population higher than that of Han,and the difference was statistically significant(P < 0.05);3.In male population,compared to BMI,SBP,DBP,waist circumference,hip circumference,neck circumference,subcutaneous fat4 thickness,UA and ALT level of the normal group,the NAFLD group was statisticallysignificant(P < 0.05);in the female population,compared to BMI,SBP,DBP,waist circumference,hip circumference,neck circumference,subcutaneous fat thickness,FPG UA,ALT and AST level of the normal group,NAFLD group was statistically significant(P < 0.05);4.In the Uygur population,compared to BMI,SBP,waist circumference,subcutaneous fat thickness,FPG,ALT and AST of normal group,NAFLD group has statistical significance(P < 0.05);In the Han population,compared to BMI,SBP,DBP,waist circumference,hip circumference,neck circumference,subcutaneous fat thickness,ALT,AST levels of normal group,NAFLD population group has statistical significance(P < 0.05);5 Past medical history and NAFLD single factor Logistic regression analysis results show that diabetes,hyperlipidemia,cholecystitis and cholelithiasis were all associated with NAFLD(P < 0.05);6.The clinical observation indexes and NAFLD single factor Logistic regression analysis show that BMI,SBP,DBP,waist circumference,hip circumference,neck circumference,subcutaneous fat,FPG,ALT,AST levels were associated with NAFLD(P < 0.05);7.Male obesity index predicts NAFLD occurrence,waist circumference,hip circumference,subcutaneous fat area,neck circumference under the curve were 0.711,0.668,0.652,0.649;Female obesity index predicts NAFLD occurrence,area around the circumference,neck circumference and subcutaneous fat under the curve were 0.790,0.760,0.710,0.697;8.After carrying out community intervention on screened community-based NAFLD patients,17 cases in intervention were cured,10 cases in control group were cured(before the intervention two groups of NAFLD prevalence was statistically tested and has comparability,=0.892,P=0.640);9.Before and after intervention,intervention group and control group of NAFLD patients,BMI,SBP,DBP,waist circumference,hip circumference,neck circumference,subcutaneous fat thickness,FPG,UA,ALT and AST levels were changed;10.At the end of the intervention period,intervention group and control group were statistically significant on BMI,SBP,DBP,waist circumference,neck circumference,fat thickness,and changes of subcutaneous UA level(P < 0.05).Conclusion: 1.NAFLD morbidity rate of middle-aged people in Urumqi community was more higher,suggesting that the Urumqi community residents should pay more attention to the prevention and treatment of NAFLD;2.NAFLD was related with many factors,including gender,age,BMI,blood pressure,waist circumference,hip circumference,neck circumference,thickness of subcutaneous fat,fasting glucose,uric acid,alanine aminotransferase,aspartate aminotransferase and so on;3.Prevention of NAFLD mainly focused on removingpathogenic risk factors,through health education,diet adjustment,scientifically and effectively control weight,regular physical examination,improve bad behaviors and habits of life,pay attention to regular exercise,usage of drug treatment and a series of comprehensive measures when necessary,to resolve NAFLD,and effectively prevent the development of diseases and occurrence of complications.