| Objective:1.To evaluate the clinical efficacy and safety of NB-UVB combined with lipoic acid in the treatments of generalized vitiligo.2.To evaluate the clinical efficacy and safety of NB-UVB combined with fractional CO2 laser and topical corticosteroids in the treatments of acrofacial vitiligo.Methods:1.This is a double-blind randomized study.Generalized vitiligo patients were enrolled in this clinical trial.Vitiligo patients were divided into group A and B randomly.Group A was defined as those who received NB-UVB three times per week and one lipoic acid tablet per day.Group B was characterized as those who received NB-UVB three times weekly and one placebo tablet daily.The efficacy of treatments was evaluated after 6 consecutive months.2.This is a randomized self-control study.Acrofacial vitiligo patients with symmetrical lesions were enrolled in this clinical trial.Participants with symmetrical lesions were divided into 2 groups(group A and B)randomly.Group A received fractional CO2 laser once every two weeks followed by topical Halometasone/Triclosancream twice daily and NB-UVB three times weekly.Group B received NB-UVB three times weekly and topical Halometasone/TriclosanCream twice daily.The efficacy of treatment was evaluated after 12 consecutive weeks.Results:1.In the trail of NB-UVB combined with lipoic acid,after 3 months treatment the marked response rates in group A and group B were 42.9%(3/7)and 12.5%(1/8)respectively(P=0.282,P>0.05).The total response rates in group A and group B were 85.7%(6/7)and 75%(6/8)respectively(P=1.0,P>0.05).After 6 months treatment the marked response rates in group A and group B were 57.1%(4/7)and 50%(4/8)respectively(P=1.0,P>0.05).The total response rates in group A and group B were 85.7%(6/7)and 75%(6/8)respectively(P=0.467,P>0.05).The results show no significantly statistical differences.Differences were found in the repigmentation rates between the different parts of the physical body after 6 months treatment.On trunk,the repigmentation rates were 52.8±38.4%and 40.4±29.7%respectively in group A and B.On acra,they were 10.5±13.7%and 0.33±0.81%respectively in group A and B.No severe adverse reactions were observed in any of the patients during the treatment.2.After the treatment of NB-UVB combined with fractional CO2 laser and topical corticosteroids,the marked response rates in group A and controlled group B were 31.25%(5/16)and 12.5%(2/16)respectively(P=0.394,P>0.05).The total response rates in group A and group B were 50%(8/16)and 31.25%(5/16)respectively(P=0.473,P>0.05).The results show no significantly statistical differences.The appearance time of the repigmentation in group A was 2.67 ± 1 weeks.And the appearance time in group B was 3.2± 1.79 weeks.The satisfaction score of group A was 5.29±2.70,higher than the score graded as 4.0±2.18 of the group B.No severe adverse reactions were observed in any of the patients during the treatment.Conclusions:1.NB-UVB is an effective and safe treatment for generalized vitiligo,the marked response rates and the total response rates were 50%and 75%respectively after 6 months treatment.Combined with lipoic acid treatment group is higher than the control group in the marked response rates and the total response rates after the same treatment.While the results show no significantly statistical differences.The reason might be the number of cases is too little,and should expand the patients for further research.This study also shows that different parts of the body has different repigmentation rates,and the trunk has a higher repigmentation rate,while the acra has low.2.NB-UVB combined with fractional CO2 laser and topical corticosteroids is effective and safe in the treatment of acrofacial vitiligo.The combined treatment group has better marked response rates and total response rates,shorter treatment time to begin repigmentation and higher satisfaction score than the control treatment group,However,the results show no significantly statistical differences.The reason might be the number of cases is too little,and should expand the patients for further research.This could be an alternative therapy for the treatment of acrofacial vitiligo,which is invalid for conventional treatment. |
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