Related Research On Changes Of Serum HCY And Hs-CRP Levels Before And After PCI By Patients Suffering Unstable Angina

Purpose: To investigate the levels of serum homocysteine(HCY)and hypersensitive C-reactive protein(hs-CRP)in patients with unstable angina and the changes before and after percutaneous coronary intervention(PCI).Methods: Objects of study were selected from patients admitted into the Department of Cardiology,Dongguan Cardiovascular Branch of Affiliated Hospital to Yan’an University from June 2015 to December 2016.Patients meeting the inclusion criteria were divided into unstable angina group,stable angina pectoris group and non-coronary heart disease group.There were 102 patients with unstable angina,including 61 males and 41 females aged(59.31±10.01)years old.There were 65 patients with stable angina pectoris,including 45 males and 20 females aged(57.62±9.28)years old.And there were 40 patients with non-coronary heart disease,including 26 males and 14 females aged(59.83±8.03)years old.The levels of HCY and hs-CRP in serum of patients were measured via enzymatic cycling assay and enzyme-linked immunosorbent assay.Whether there were statistically significant differences among the three groups was analyzed.According to whether the patients with unstable angina received PCI,they were divided into PCI group(n=62,including 35 males and 27 females)and non-PCI control group(n=40,including 26 males and 14 females).The levels of HCY and hs-CRP were measured before PCI and at 1d,3d and 7d after PCI,followed by statistical analysis.Results: 1.The levels of serum HCY and hs-CRP in unstable angina group were increased compared with those in stable angina pectoris group and non-coronary heart diseasegroup(p<0.05).2.There were no significant changes in serum HCY levels in patients with unstable angina at 1d and 3d after PCI(p>0.05),but the levels were decreased significantly at 7d after PCI compared with those before PCI(15.09±5.73 VS 20.44±5.74,p<0.05).3.The levels of serum hs-CRP in patients with unstable angina were increased at 1d and 3d after PCI compared with those before operation(p>0.05),and returned to the preoperative levels at 7d after PCI,and there was no significant difference compared with that before operation(p>0.05).Conclusion: 1.Serum HCY and hs-CRP levels can reflect the severity of angina pectoris patients;2.PCI may reduce the level of serum HCY in patients with unstable angina,but the mechanism is still unclear,and further research is pending;3.Serum hs-CRP can respond to inflammatory changes in the early postoperative,it can be used to observe the curative effect after PCI.