| Objective: To study the risk factors and coronary artery lesion characterstics in female patients with coronary heart disease,which may have an influence on the strategies for prevention for coronary heart disease in female patients.Methods:1 A total of 375 patients who underwent coronary angiography were randomly enrolled from August 2016 to March 2017 in the Department of cardiovascular medicine,the Second Hospital of Hebei Medical University.These patients were divided into three groups: group one were femeal with coronary heart disease,with a total of 151 cases,among which 34 cases were diagnosed with acute myocardial infarction;group two were female without coronary heart disease,with a total of 61 cases;and group three were male with coronary heart disease,with a total of 163 cases,among which 62 cases were diagnosed with acute myocardial infarction.2 Collect all female patients` general condition,which includes age,Body Mass Index and basic heart rate,and collect their common risk factors for coronary heart disease,such as total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,triglycerides,history of hypertension,diabetes,smoking history,history of menopause,early family history of coronary heart disease,etc,and collect their newly reported risk factors for coronary heart disease,such as apolipoprotein A,apolipoproteinB,total bilirubin,direct bilirubin,indirect bilirubin,homocysteine,fibrinogen,blood uric acid,serum folic acid,Vitamin B12,C-reactive protein,anticardiolipin antibody.Analyze the risk factors in female patients with coronary heart disease.3 Analyze the type and location of coronary artery lesion in femalepatients with coronary heart disease compared with male with coronary heart disease.4 Creating a database through the application of SPSS 19.0 software package for statistical analysis.Measurement data is expressed as mean ±standard deviation,comparison among groups in independent sample t test.Count data is expressed as a percentage,differences between the two groups are compared using the χ2 test.Multivariate Logistic regression analysis is used to find the risk factors of female patients with coronary heart disease.P<0.05 was considered statistically significant.Results:1 Comparison of common risk factors for coronary heart disease: there was no statistically different(P>0.05)in basic heart rate,smoking history and total cholesterol between female with CHD and without CHD.The average age of female with CHD was 62.04±9.02,while 56.20±7.99 in female without CHD,the diffrence was statistically significant(P <0.05).The average BMI was 25.89±3.37kg/m2 in female with CHD,and 24.35±1.84 kg/m2 in female without CHD,BMI in female with CHD wass higher than female without CHD(P < 0.05).The average HDL-C in female with CHD(1.12±0.29mmol/L)was lower than that in female without CHD(1.22±0.27mmol/L),the diffrence was statistically significant(P<0.05).The average LDL-C in female with CHD(2.84±0.69 mmol/L)was higher than that in female without CHD group(2.56±0.49mmol/L),the diffrence was statistically significant(P<0.05).The average TG in female with CHD was 1.93±0.93mmol/L,higher than that in female without CHD(1.47±0.68mmol/L),the diffrence was statistically significant(P<0.05).There were 111 cases(73.51%)with history of hypertension in female with CHD,and 30 cases(49.18)with history of hypertension in female without CHD,the diffrence was statistically significant(P <0.05).There were 41cases(27.15%)with history of diabetes in female with CHD,and 5 cases(8.20%)in female without CHD,the diffrence was statistically significant(P <0.05).139 cases(92.05%)with menopause in female with CHD,47 cases(77.05%)with menopause in female without CHD,the diffrence was statistically significant(P <0.05).There were 32 cases(21.19%)with early family history of coronary heart disease in female with CHD,4 cases(6.56%)in female without CHD,the diffrence was statistically significant(P <0.05).2 Comparison of newly reported risk factors for coronary heart disease:There was no statistically different(P>0.05)in apolipoprotein B and ACL between female with CHD and female without CHD.The average apolipoprotein A was 1.23±0.18g/L in female with CHD,higher than that in female without CHD(1.32±0.20g/L),the diffrence was statistically significant(P<0.05).The average total bilirubin,direct bilirubin,indirect bilirubin were9.04±2.99umol/L,2.91±0.90umol/L,6.06±2.39umol/L,lower than that in female without CHD(10.24±4.21umol/L,3.23±1.22umol/L,7.02±3.13umol/L),the diffrence was statistically significant(P<0.05).The average homocysteine was 14.69±2.35umol/L in female with CHD,higher than that in female without CHD(10.27±1.66umol/L),the diffrence was statistically significant(P<0.05).The average fibrinogen was 3.37±0.54g/L in female with CHD,higher than that in female without CHD(3.00±0.41g/L),the diffrence was statistically significant(P<0.05).The average blood uric acid was 292.26±86.72umol/L in female with CHD,higher than that in female without CHD(260.41±67.17umol/L),the diffrence was statistically significant(P <0.05).The average serum folic acid in female with CHD(5.43±2.15ng/mL)was lower than that in female without CHD(6.29±2.35ng/mL),the diffrence was statistically significant(P <0.05).The average Vitamin B12 in female with CHD(380.39±108.02pg/mL)was lower than that in female without CHD(413.02±107.61pg/mL),the diffrence was statistically significant(P<0.05).The average C-reactive protein is 5.33±4.70mg/L in female with CHD,3.91±3.30mg/L in female without CHD,the average C-reactive protein is higher in female with CHD(P<0.05).3 Binary logistic regression analysis shows that the history of menopause,early family history of coronary heart disease,triglycerides,homocysteine and serum folic acid were independent risk factors for female patients with CHD(P<0.05).4 Coronary artery lesion characterstics in female patients with coronary heart disease: There was no statistically different(P>0.05)in double vessel lesion,anterior descending artery lesion,circumflex artery lesion and right coronary artery lesion between female with CHD and male with CHD.Single vessel lesion in female with CHD(66cases,43.71%)was more than that in male with CHD(51cases,31.29%),the diffrence was statistically significant(P<0.05).Triple vessel lesion in female with CHD(45cases,29.80%)were less that in male with CHD(66cases,40.49%),the diffrence was statistically significant(P<0.05).There were 5 cases(3.31%)in female with CHD left main coronary artery lesion,less than that in male with CHD(19cases,11.66%).Conclusions:1 Age,BMI,high density lipoprotein cholesterol,low density lipoprotein cholesterol,triglycerides,hypertension,diabetes,history of menopause,early family history of coronary heart disease,apolipoprotein A,total bilirubin,direct bilirubin,indirect bilirubin,homocysteine,fibrinogen,blood uric acid,serum folic acid,Vitamin B12,C-reactive protein are different in female with CHD and without CHD.2 Triglycerides,History of menopause,early family history of coronary heart disease,homocysteine and serum folic acid are independent risk factors for female patient with coronary heart disease.3 In female patient with coronary heart disease,single vessel lesion was more than that in male with CHD,while triple vessel lesion and left main coronary artery lesion were less that in male with CHD. |
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