Clinical Study Of Risk Factors And Percutaneous Coronary Intervention In Elderly Female Patients With Coronary Artery Disease

Objective: to investigate the differences between old female patients and middle-aged female patients suffering from coronary heart disease in terms of risk factors and coronary pathological characteristics.Method: After collecting 402 female with chest pain (age≥50) who underwent the examine of coronary angiography in our hospital between January, 2005 and October, 2006. We compared the risk factors, general situation, pathological character of coronary heart disease, character of intervention therapy and short-term prognosis among them. Statistical method: measurement data were processed via standard deviation ( x±S), Intra-team comparison were conducted via t-test (P<0.05); enumeration data were processed viaΧ2 test (P<0.05); SPSS11.5 software were utilized to analyze the data.Results:1.Risk factors comparison: No differences in comparison in terms of Hypertension history, Diabetes Mellitus history, smoking history, cholesterol, triglyceride, HDL-C, LDL-C between elderlyfemale group and middle-aged female group.2.There was a statistical difference between elderly hyperuricemia group and middle-aged hyperuricemia group in terms of coronary heart disease incidence. And there was also a statistical difference between elderly hyperuricemia group and elderly group with normal UA level in terms of coronary heart disease incidence.3.According to the levels of HGB, the elder female group was divided into five sub-groups. And there was a statistical difference between HGB<110g/L group and 120≤HGB<130g/L group in terms of coronary heart disease incidence, and this difference also be seen between 110≤HGB<120g/L group and 120≤HGB<130g/L group. The lower the level of HGB the higher the coronary heart disease incidence.4.Key points of atherosclerosis: In middle-aged CHD group, the rate of single branch coronary atherosclerosis subjects was 63%; the same ratio in elderly CHD group was 38.8%. Thus there was significantly statistical difference between the two groups. In group mid, the ratio of 50%- 75% degree of coronary stricture is 35.4%; the same ratio in elderly CHD group is 25.7%. Thus there wassignificantly statistical difference between the two groups (P<0.05).5.Follow up: The number of missing subjects in group 2 and group 1 was 3 and 1 respectively due to artificial reasons. After the percutaneous coronary intervention operation, the occurrence of myocardial infarction, secondary angina pectoris, myocardial dysfunction, sudden cardiac death were 1,3,3,3 in group 1; the occurrence of secondary angina pectoris, myocardial dysfunction were 1,1 in group 2.Conclusion: 1.The level of hemoglobin (HGB<120g/L) was related with the incidence of coronary heart disease in aged female patients. 2.The elderly female with hyperuricemia had more incidence of coronary heart disease than that with normal level of UA. 3.The coronary pathological changes in aged female subjects was more complex than middle-aged female patients. 4.The MACE of the aged female which was accepted PCI was more than that of middle-aged one.