The Correlationships Of Perfusion MR Imaging From Glioblastoma And IDH1 Mutations State

Objective:Glioblastoma multiforme is highly aggressive and the most common type of primary malignant brain tumor in adults.Imaging biomarkers may provide prognostic information for patients with this condition.Patients with glioma with isocitrate dehydrogenase(IDH1)mutations have a better clinical outcome than those without such mutations.Our purpose was to investigate whether the IDH1 mutation status in glioblastoma multiforme can be predicted by using MR imaging.Methods:We retrospectively studied 30 patients with glioblastoma multiforme with wild type IDH1 and 30 patients with mutant IDH1.Ktrans and Ve within the enhancing portion of each tumor were measured by using DCE-MRI data.rCBF and rCBV within the enhancing portion of each tumor were measured by using DSC-MRI.Each of the parameters was compared between patients with wild type IDH1 and mutant IDH1 by using the T-test.The performance in discriminating between the entities was evaluated by using receiver operating characteristic analysis.Results:Ktrans,Ve,rCBF and rCBV inside the enhancing lesion were significantly higher in patients with wild type IDH1 than in those with mutant IDH1(P<0.05 each).The area under the curve for Ktrans,Ve,rCBF,and rCBV inside the enhancing lesion were0.850,0.873,0.739,and0.772,respectively.Conclusion:Ktrans,Ve,rCBF,and rCBV calculated from MR imaging are useful for predicting the IDH1 mutation status.