Research On Relevance Between Expiratory Nitric Oxide Level And Inflammation Phenotype Of Bronchial Asthma Patients In Eastern Fujian

Objective: 1)Relevanced between FENO value,inflammatory phenotype and lung function in adults living in Eastern Fujian Province were explored to offer new clues for classification of inflammatory phenotype,treatment and prognosis of asthma;2)Disparity of expiratory NO concentration,inflammatory phenotype and lung function between bronchial asthma patients of Han people and those of She ethnic minority in Eastern Fujian were dealt with.Methods: 120 patients(60 Han people in experimental group and60 She ethnic minority in control group)who were clearly diagnosed with adult bronchial asthma are selected from the Respiratory Department of A Third Hospital Hospital between January 2016 and February 2017.All selected patients receive examinations of FeNo,induced sputum cell count and lung function,etc.The function of FeNO in bronchial asthma diagnosis and management were evaluated through comparing FeNO level,asthma inflammatory phenotype and lung function of patients from different ethnic groups and analyzing relevance between FENO value,inflammatory phenotype and lung function of asthma patients.Results:1.The separate Chi-square tests on induced sputum cells from both experimental group and control group attained a Chi-square value of8.414,P<0.05,which is statistically significant.2.Lung function tests on both experimental group and control group attained a Chi-square value of 1.982,P>0.05,which is statisticallyinsignificant.3.Anova of variance on FeNO value of asthma patients from both experimental group and control group attained mean 49.03 ± standard deviation 18.19 for experimental group and mean 33.43 ± standard deviation 12.58 for control group,P<0.05,which is statistically significant.4.The correlation coefficient r between FeNO level and differential induced sputum cell(paucigranulocytic,neutrophilic,mixed and eosinophilic)of bronchial asthma patients in Eastern Fujian equals0.580(p<0.01),which indicates positive correlation.5.The correlation coefficient r between FeNO level and lung function of bronchial asthma patients in Eastern Fujian equals-0.546(p<0.01),which indicates negative correlation.Conclusions:1.There were differences in differential cell counts in induced sputum between adult bronchial asthma patients of Han people and those of She ethnic minority in Eastern Fujian,which indicated that ethnic difference could influence sputum cell counts.2.The difference of lung function between adult bronchial asthma patients of Han people and those of She ethnic minority in Eastern Fujian were insignificant,which indicated no influence of ethnicity on lung function.3.There were differences in expiratory NO level between adult bronchial asthma patients of Han people and those of She ethnic minority in Eastern Fujian,which indicated ethnic influence on FeNO level.4.Significant positive correlation exists between FeNO level and differential induced sputum cell(paucigranulocytic,neutrophilic,mixed and eosinophilic)of asthma patients in Eastern Fujian,which indicated the FeNO level of eosinophilic asthma patients is related totheir eosinophilic airway inflammation.5.Significant negative correlation existed between FeNO level and lung function of asthma patients in Eastern Fujian,which indicated certain correlation between FeNO and severity of airway obstruction.Serious pulmonary function impairment indicates major obstruction of airway and lower FeNO level whereas mild pulmonary function impairment indicated minor obstruction of airway and higher FeNO level.