| Liver cirrhosis is a common disease caused by different causes of chronic liver, progressive, diffuse lesions, with a high prevalence rate, prolonged course, more complications, treatment is difficult, characteristic aggravation, high fatality rate. Clinical on the damage of liver function and portal hypertension as the main performance, divided into compensatory and decompensated period. Decompensation often appears ascites, upper digestive tract bleeding complications, hepatic encephalopathy, secondary infection, the cause of death is one of the common diseases in China and the main.Liver disease will affect the characteristics of pulse, pulse performance can also reflect the type, severity and prognosis etc.The pulse is an important diagnostic information, traditional pulse main doctor with experience and subjective feeling, strong subjectivity. In view of the subjectivity of pulse acquisition, and reflect the complexity and variety of information, this study in order to play advantage and improve the objectivity of the pulse for the purpose, with the help of Electropulsograph collected 144 cases of decompensated hepatitis B cirrhosis patients in the intervention of traditional Chinese medicine before treatment, TCM Intervention after three months of treatment, the intervention of traditional Chinese medicine treatment for six months,then collected their pluse graphical, to explore the pulse parameters and significance of decompensated hepatitis B cirrhosis changes in Chinese medicine intervention treatment. Objective:Through clinical epidemiological survey, collecting 144 cases of patients with decompensated hepatitis B cirrhosis intervention before Chinese medicine treatment, three months,six months with traditional Chinese medicine treatment,and then Collect every point of the pulse parameters.and syndrome integral with Chinese medicine treatment there months,six month,and before Chinese medicine treatment,with the qi deficiency syndrome, qi stagnation syndrome, blood stasis.To explore the pulse parameters characteristics of patients with decompensated hepatitis B cirrhosis, and analyze the changes before and after the intervention of pulse parameters, different syndromes of the change of pulse parameters characteristics, evaluation for clinical diagnosis and treatment of decompensated hepatitis B cirrhosis to provide certain reference.Method:1 Collecting casesAccording to the inclusion and exclusion criteria, collected in accord with the diagnosis standard of hepatitis B cirrhosis patients.2 Chinese medicine intervention treatmenThe included patients were randomly divided into three groups, each group of 48 cases. In the basic treatment of Western Medicine (antiviral nucleoside antiviral treatment) on the basis of, the 3 groups of patients were given placebo or granule.3 The time of interventionThe intervention lasted six months, divided into three points, respectively, before intervention (baseline), after third months, sixth months of intervention.4 Syndrome integral acquisitionThe use of "decompensated hepatitis B cirrhosis patients with clinical symptoms were collected in the collection table", collection the Syndrome integral in the intervention of traditional Chinese medicine syndromes before treatment, TCM Intervention Treatment for third months, the intervention of traditional Chinese medicine treatment for sixth months.5 Pulse parameters acquisitionUse Shanghai University of Traditional Chinese Medicine and Shanghai Pacific Computer Information System Co. Ltd. jointly developed SmartMX-I type pulse instrument produced by. Collection of patients in the intervention of traditional Chinese medicine pulse parameters before treatment, TCM Intervention Treatment for third months, the intervention of traditional Chinese medicine treatment for sixth months.6 The establishment of the databaseUse SmartMX-I type pulse instrument analysis software, pulse graph parameters are derived to the excel table, by two independent back-to-back exporting and derived data entry to SPSS 19.0, and with the original data check, check and correct after locking the database; two independent back to back calculation in the database before the intervention, intervention of three months, six months of qi deficiency syndrome, qi stagnation syndrome, blood stasis syndrome integral intervention. The calculated results entry to SPSS 19.0 and the results are not consistent with the local check, until the calculated.7 Statistical analysisBy using the statistical software SPSS, through description statistics, multi group repeated measures design analysis of variance and non parametric test statistics of the collected data for statistical analysis, P< 0.05 for differences were statistically significant.Result:144 patients with decompensated hepatitis B cirrhosis patients, including 98 cases of male, female 46 cases.A total loss of 11 cases. Incomplete data (three points of TCM treatment, the lack of data before treatment, third months of treatment, the treatment of any data, sixth months of data for incomplete data is not included in the study). This study included 113 cases, including 77 cases of male, female 36 cases; 2 cases aged 20-29 years, 30-39 years old 8 cases,40-49 years old 52 cases,38 cases aged 50-59 years,60-65 years old 13 cases; the minimum age of 28 years, the maximum age of 65 years, mean age 48.96± 8.271 years old.1 The overall characteristics of pulse parameters(1) The overall intervention characteristics of pulse parameters before treatment.(2) The differences of the values of the pulse parameters w, t1, h3/h1, h4/h1 and t1/t were statistically significant (P< 0.05), and the values of the parameters of the above veins were lower than that of female.(3) Pulse graph parameters t5, h3/h1, h4/h1, h5/h1, t5/t4 value differences among different age groups was statistically significant (P<0.05) and above the pulse diagram parameters with the age increased value increased gradually.Patients with decompensated hepatitis B cirrhosis enrolled in the study, the average age was higher in female patients than in male patients, female patients with left ventricular ejection period, to maintain high level of arterial pressure in a long time. May be the difference between the high age and gender, left ventricular systolic function in female patients than in male patients with weak, left ventricular ejection rate in female patients than male patients decreased.With the increase of age, left ventricular in patients with decompensated hepatitis B cirrhosis of the relaxation time change, vascular compliance, peripheral resistance, arterial compliance relatively poor. 2 Changes in pulse parameters before and after the compensation period of Chinese medicine treatment of hepatitis B liver cirrhosis patients with different gender(1)Three at the age of 77 male patients with decompensated hepatitis B cirrhosis patients with difference of pulse parameters between no statistical significance(P>0.05).(2)In 77 cases of male patients in "tonifying and regulating Qi, promoting blood circulation group"," tonifying and regulating Qi, promoting blood circulation, nourishing yin and blood group", "placebo" treatment effect, In before treatment, treatment of the third month, treatment of the sixth month of pulse graph parameters multibody repeated design data variance analysis, time, drugs, and drug interaction results. There were no significantly differences statistically significant.(3)The age of two in 36 patients with decompensated hepatitis B cirrhosis patients with female difference pulse parameters between no statistical significance.(4)In 36 cases of female patients in " tonifying and regulating Qi, promoting blood circulation group"," tonifying and regulating Qi, promoting blood circulation, nourishing yin and blood group", "placebo" treatment effect, before treatment, long pulse parameters were third months, sixth months of treatment with repeated variance meter data the analysis, we found that different intervention time of pulse parameters t5 value was statistically significant; pulse parameters of t5 in different drugs was statistically significant difference between the groups; pulse parameters of t in different drugs was statistically significant difference between the groups was statistically significant; pulse parameters of t5/t4 in different treatment groups.3 Study on the pulse parameters of qi deficiency, qi stagnation syndrome, blood stasis syndrome of different changes in patients before and after intervention(1)113 patients according to the syndrome before and after the intervention did not change, some points are divided into three groups, significant change, No change, some change, three groups. Of qi deficiency syndrome, qi stagnation syndrome, blood stasis syndrome of the three groups of patients with gender, age of the chi square test for non parametric test, The differences of the pulse parameters between the three groups were not statistically significant, and the differences were not statistically significant between different ages.(2) With the deficiency of qi deficiency syndrome, the improvement of the syndrome score, the pulse parameters h3, h4 and t are decreased.(3) With the stagnation of qi stagnation syndrome, the improvement of the syndrome score, the pulse parameters t, the t5 values, and the tl/t values are decreased.(4) With the improvement of blood stasis syndrome integral, pulse graph parameters T5 produced from baseline has significant difference to no statistically significant changes in three months intervention; pulse graph parameters ad produced from the baseline and three months have significant difference to intervene in six months without significant difference.Conclusion:1 Have a certain effect of pulse parameters of age and gender on decompensated hepatitis B cirrhosis. In decompensated hepatitis B cirrhosis patients with different gender, attention to the effect of age and gender on pulse parameters, we should pay more attention to the high age of female patients with left ventricular ejection function of vascular wall and older patient compliance and peripheral resistance.2 The effect of different time, the intervention, the time and the interaction of drugs on the pulse parameters of the patients are different.3 The intervention effect of different drug groups may have different effects on t, t5/t4 pulsation in women, different intervention time has a certain effect on female patients with pulse parameters t5 value.That for patients with decompensated hepatitis B cirrhosis women, can detect the pulse parameters t, t5, t5/t4 value in response to changes in patients with left ventricular diastolic and pulse period, heart rate.4 Pulse parameters in the syndrome integral change under different situations, can reflect the blood running situation of patients with decompensated hepatitis B cirrhosis, especially some pulse parameters such as Qi deficiency syndrome in patients with h3, h4, t decreased, Qi stagnation syndrome in patients with t5, t increased, tl/t decreased, changes of blood stasis in patients with t5, ad, can provide a reference for clinical diagnosis and treatment evaluation. |
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