The Study Of Ixeris Sonchifolia Total Flavonoids Granules Processes And Quality Standard

Cardiovascular and cerebrovascular diseases are very common which seriously threaten to people's health,occupy the top of the various kinds of causes of death.Modern research shows the extracts of Ixeridium sonchifolium are very effective and widely used in the treatment of cardiovascular and cerebrovascular diseases.We extract and purify the aboveground parts of lxeridium sonchifolium,and use effective parts as medicine.The total flavones from Ixeridium sonchifolium as active ingredients,are prepared into granules in order to guarantee therapeutic effect and carry and take easily.Based on the main properties of the flavonoids,the extraction and purification process of The Ixeris sonchifolia total flavonoids granules was designed.The leaching amount of total flavonoids was considered as standard of the extraction technology,influencing factors contain the extraction hours?extraction times?extraction solvents and their weight.In the various methods of purification of total flavonoids,resin adsorption best fits industrial production,and the resin can be reused so that the production cost is low.Therefore purification process route is designed in accordance with standards of leaching amount and relative content of total flavonoids,the enrichment degree of the total flavones from Ixeridium sonchifolium in the different types of resin,determine the tuning parameters of resin purification.In order to strictly control quality of products,ensure the safety and validity of clinical medicine,we carried out research about standards of products quality.General inspection items?inspection methods and quality control indexes used for quality control of products were studied and established;By TLC we create a qualitative identification method of luteolin with good specificity and separation;Because flavonoids form complex with aluminum salt features so that obtain stable characteristic absorption peaks,we studied the determination method for the total flavones from Ixeridium sonchifolium by spectrophotometry,and determined wavelength?time and operation steps,the method which is simple and has good accuracy?repeatability and stability in line w:ith the requirements of content analysis and measurements;By HPLC the determination method for luteolin is established,which is sensitive?accurate?reproducible and reliable,and can be used to determine content of flavonoid aglycone luteolin,we achieve the production?transportation?storage and use of The Ixeris sonchifolia total flavonoids granules under control,to further ensure the stability of the quality of drugs and the validity of clinical use.The investigation on the preparation stability showed that,The Ixeris sonchifolia total flavonoids granules was placed in six months under accelerated conditions,indicators measured arc within the scope of-quality standards required,there is no significant change,indicating good stability of the preparation.