The Value Of Monocyte To High-Density Lipoprotein Cholesterol Ratio In Cardiac X Syndrome

Background and objectiveClinically,we often encounter angina or angina pectoris patients,coronary angiography normal or near normal.As early as 1973,Kemp first defined it as‘Syndrome X’.Now,the syndrome is called‘cardiac X syndrome’and refers to clinical symptoms in patients with angina or similar angina,clinical signs of treadmill exercise,and normal or substantially normal coronary angiography findings.Cardiac X syndrome is a heterogeneous syndrome that involves different mechanisms,abnormal coronary artery dilation caused by endothelial dysfunction,inflammatory response,estrogen deficiency,hypertension,insulin deficiency or insulin resistance,and abnormalities in pain perception.In the pathogenesis of heart X syndrome,the inflammatory response is an important cause of cardiac X syndrome.Monocyte-to-HDL cholesterol ratio(MHR)is a newly discovered inflammatory index in recent years.There are many studies that show that it is associated with the occurrence of cardiovascular disease and is associated with coronary stenosis The degree is positively correlated,foreign studies have shown that MHR as a new inflammatory factor,involved in the occurrence and development of cardiac X syndrome.Due to the complex mechanism of heart X syndrome,more risk factors,so far there is no uniform diagnostic criteria,clinically mainly rely on the exclusion of diagnosis,need to rule out epicardial coronary artery stenosis,abnormal coronary artery,spasm,left ventricular Hypertrophy,and other similar causes of angina that have nothing to do with heart disease such as esophageal motility disorders,fibromyalgia and costochondritis.Therefore,clinical diagnosis is difficult.Patients often suffer from angina pectoris and repeated hospitalization,coronary angiography results show normal or no obvious stenosis and neglect the treatment,some patients even repeated coronary angiography,which has brought great social and patient financial burden.The MHR acquisition method is simple,no geographical restrictions,This article aims to explore the application of MHR in cardiac X syndrome.MethodsA total of 140 patients diagnosed with Cardiac X syndrome at the First Affiliated Hospital of Zhengzhou University from January 2016 to August 2017 were selected and compared with 140 healthy subjects in the same period at the physical examination center of our hospital.The age,gender,medical history(hypertension,diabetes mellitus),white blood cell count,neutrophil count,lymphocyte count,monocyte count,platelet count and thrombocytopenia were recorded in the patients and the control group.Enzymatic colorimetric assay for total cholesterol(T-CHO),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),etc.Calculate MHR=Monocyte Number(10~3/L)/High Density Lipoprotein Cholesterol(mg/dl).After 3 months of taking standard drug therapy,the patients were divided into treatment-effective group and treatment-ineffective group according to the therapeutic effect.The above two groups were compared and analyzed.To explore the value of MHR in cardiac X syndrome.Results1.Compared with the control group,the incidence rate of hypertension in cardiac X syndrome group was higher than that in the control group.The number of mononuclear cells,platelet count increased,the thrombocytopenia increased and the MHR increased,the difference was statistically significant.2.Treatment effective group compared with the treatment of ineffective group,treatment ineffective group increased monocyte count,low density of high density lipoprotein,MHR increased,the difference was statistically significant.3.Logistic regression analysis showed that MHR,platelet count,and thrombocytopenia were correlated with the occurrence of cardiac X syndrome.There was no significant correlation between MHR and the short-term prognosis of cardiac X syndrome.Conclusion1.Patients with cardiac X syndrome,high proportion of high blood pressure,MHR,platelet count,and thrombocytopenia were significantly increased,which is a risk factor for cardiac X syndrome.2.MHR in the diagnosis of cardiac X syndrome has a certain value.3.MHR and the short-term prognosis of cardiac X syndrome no significant correlation.