Correlation Between Variations Of Monocyte To High-density Lipoprotein Cholesterol Ratio And Metabolic Syndrome In Perimenopausal And Postmenopausal Women

Objective: To explore the variations of monocyte to high-density lipoprotein cholesterol ratio(MHR)in different reproductive stages and metabolic diseases(pre-obesity,prediabetes,metabolic syndrome)of perimenopausal and postmenopausal women by collecting the general clinical data.Methods: Perimenopausal and postmenopausal women who underwent routine physical examination at the Physical Examination Center of Zhongda Hospital Affiliated to Southeast University from September 2021 to December 2021,were enrolled.The general clinical data and laboratory test indicators(white blood cell count,lymphocyte count,platelet count,neutrophil count,monocyte count,high-density lipoprotein cholesterol,triglyceride,total cholesterol,low-density lipid Protein cholesterol,uric acid,fasting blood glucose)were collected.The MHR,lymphocyte to monocyte ratio(LMR),platelet to lymphocyte ratio(PLR),neutrophils to lymphocyte ratio(NLR)were calculated.According to different reproductive stages(stages of reproductive aging workshop+10),different metabolic diseases(pre-obesity and pre-diabetes),and no matter or not they had metabolic syndrome,the variations of MHR were evaluated.The risk factors of MS and the predictive ability of MHR for metabolic syndrome in perimenopausal and postmenopausal women were investigated by the methods of correlation analysis,binary logistic regression analysis and ROC curve analysis.Results: 1.A total of 594 patients were included in the analysis,according to STRAW+10,the research subjects were divided into: early menopause transition group(n=75),late menopause transition group(n=97),early postmenopausal group(n=250),and late postmenopausal group(n=172),there was no significant difference in MHR among different reproductive stages(P=0.625).2.Stratified analysis by different metabolic diseases:according to the Chinese obesity diagnostic criteria,the obese and underweight subjects were excluded,and the subjects were divided into a preobesity group(n=159)and a normal-weight control group(n=380).The MHR of the pre-obesity group was greater than that of the normal-weight group(0.25 vs 0.21,P<0.001).MHR was correlated with BMI(rs=0.270,P<0.001).Excluded those with a history of diabetes and abnormal blood sugar that had reached the diagnosis of diabetes,and divided the subjects into a pre-diabetes group(n=47)and a normal blood sugar control group(n=472),the MHR in the pre-diabetes group was greater than that in the normoglycemic control group(0.24 vs 0.21,P=0.020).There was no correlation between MHR and fasting glucose(rs=0.056,P=0.203).3.Stratified analysis by the occurrence of metabolic syndrome in perimenopausal and postmenopausal women: according to the diagnostic criteria,collected indicators and past medical history of metabolic syndrome,the samples of blood sugar and dyslipidemia,obesity and pre-obesity in the control group were excluded,and the research subjects were divided into the metabolic syndrome group(n=112)and the control group(n=274).The MHR of the metabolic syndrome group was greater than that of the control group(0.27 vs 0.20,P<0.001).There was a correlation between MHR and metabolic syndrome(rs=0.408,P<0.001).The results of binary logistic regression analysis showed that MHR,NLR,uric acid,and white blood cells were the risk factors for the occurrence of metabolic syndrome.The diagnostic cut-off of MHR for perimenopausal and postmenopausal women with metabolic syndrome was 0.210×109/mmol,the area under the curve was 0.760(95%CI 0.709-0.810,P<0.001),the sensitivity was 79.5%,and the specificity was 79.5%.The sensitivity was 62.1%;when MHR was combined with NLR and uric acid,the area under the curve was 0.834(95%CI 0.791-0.877,P<0.001),the sensitivity was 73.2%,and the specificity was 79.9%.Conclusions: 1.The MHR in the four stages of early menopause transition,late menopause transition,early post menopause and late post menopause were no statistically significant difference.2.The MHR of pre-obesity and pre-diabetes patients were significantly increased in perimenopausal and postmenopausal women,suggesting that MHR can reflect the metabolism of glucose and lipids in the human body.3.The MHR was significantly increased in patients with metabolic syndrome,which was an independent risk factor for metabolic syndrome,and has diagnostic value for metabolic syndrome in perimenopausal and postmenopausal women.The predictive value of MHR combined with NLR and uric acid in perimenopausal and postmenopausal women with metabolic syndrome would be higher than individual indicators.