| Research backgroundRed blood cell distribution width(RDW)is one clinical parameter conveniently obtained from the standardized complete blood count(CBC).RDW reflects the heterogeneity of red blood cell(RBC)volume and is generally represented using the variation coefficient of RBC volume.RDW is routinely used for the diagnosis of various types of anemia.However,a large number of studies have shown that RDW is also closely associated with the development of heart failure,atrial fibrillation,and acute myocardial infarction.Therefore,changes in RDW may play an important role in the progression as well as the prognosis of such cardiovascular diseases.Mounting evidence has also established that changes in RDW values are associated with dyslipidemia,high sensitive C reactive protein,renal dysfunction the traditional cardiovascular risk factors so that RDW has been proposed as both a new prognostic indicator and an independent risk factor for cardiovascular diseases.As cerebrovascular and cardiovascular diseases share a similar risk factor profile as outlined above RDW may also play an important part in evaluating the severity and progression of both diseases,the top killers of human beings.Currently,RDW researches in China and abroad mainly involve patients,and there is scarce literature targeting the general physical examination population.As such there is lack of well-defined normal reference value range for RDW in the current research field,especially with regard to age and sex.Research objective1)To investigate if there is any association between RDW and the population CVRFs of total cholesterol,high-density lipoprotein cholesterol,low density lipoprotein cholesterol,triglyceride,triglyceride,serum creatinine,blood urea nitrogen and blood uric acid.2)To further analyze the age and sex differences in RDW values in subpopulation of normaland abnormal CVRF groups if there correlations of RDW and CVRFs could be established.3)To define RDW reference range and its application in the evaluation of early-stage cardiovascular diseases.Research objects and methodsData of 45210 healthy individuals who had health maintenance physical examinations performed at Huaihe Hospital of Henan University from 200 X to 200 y were collected and analyzed.The following cases were excluded: those without routine blood work and biochemical indexes;those found to have hematological diseases,autoimmune diseases,active respiratory diseases,and abnormal WBC counts.A total of 27978 people were finally analyzed.The mean age of the study population was 46 years old(ranging 35-57),of which 14603 being male(52.2%)with an average age of 47 years old(ranging 37-58)years old and 13375 being female(47.8%)with an average age of 45 years old(ranging 34-56).The VLOOKUP function from EXCEL software was used for data sorting and classification.Software SPSS20.0 was used for statistical analysis.Independent correlation nonparametric Wilcoxon test was used to compare the differences between two groups.Multiple independent correlation nonparametric Kruskal Wallis test was used to compare the differences among groups.Correlation analysis was performed using Spearman test.Research results1.The correlation analysis showed that male age,blood creatinine,blood urea nitrogen,blood uric acid,red blood cell distribution width,triglyceride,low density lipoprotein four digits were higher than women(P<0.01),female red blood cell distribution group,high density lipoprotein was greater than male(P<0.01),and there was no statistical difference between male and female in total cholesterol group Differences(P=0.865).2.Kruskal Wallis test showed that the RDW ranges of different sexes were statistically different in all age groups(P*<0.01).Wilcoxon test showed that there was a difference in RDW between males and females at 21~60 years(P#<0.01).3.The Spearman test showed that,female group,RDW was positively correlated with age(r=0.109* p =0),total cholesterol(r=0.032** p =0),and high density lipoprotein(r=0.028** p=0.01);and decreased with the increase of blood uric acid(r= –0.021* p=0.014).In the male RDW increased with age(r=0.247** p=0),blood urea nitrogen(r=0.067** p=0),total cholesterol(r=0.022** p =0.007),and high density lipoprotein(r=0.023** p =0.005),and decreased with the increase of serum uric acid(r= –0.020* p = 0.013)and triglyceride.(r**,p <0.01,a significant correlation;r*,p < 0.05,a significant correlation.)4.Kruskal Wallis test showed that the RDW ranges of different sexes were statistically different in all age groups(P*<0.01).Wilcoxon test showed that there was a difference in RDW between males and females at 21~60 years(P#<0.01).Normal group and abnormal group of total cholesterol found that 31~40 years old,51~60 years old,more than 81 years old RDW range has significant statistical difference(P#<0.05).The RDW range of total cholesterol,blood uric acid and high-density lipoprotein cholesterol were statistically different among different age groups(P*<0.01).5.The male blood urea nitrogen,blood uric acid,triglyceride,total cholesterol group,high density lipoprotein were divided into normal group and abnormal group.The two groups were compared by Wilcoxon nonparametric test,and the different age groups of each group were analyzed by Kruskal Wallis test(P<0.05 statistics were different).The RDW range of the normal group and the abnormal group found that 71~80 years(blood urea nitrogen);31~50 years old(blood uric acid);21~30,51~60,71~80(triglyceride);21-30 years old(total cholesterol);there was a statistical difference(P#<0.01).The RDW range of serum uric acid,blood urea nitrogen and high-density lipoprotein had statistical difference among different age groups(P*<0.01).The RDW range of the normal range of triglyceride and total cholesterol was statistically different in different age groups(P*<0.01)Conclusion1.In female group RDW was positively correlated with age,total cholesterol,and high density lipoprotein;and decreased with the increase of blood uric acid.2.In the male RDW increased with age,blood urea nitrogen,total cholesterol,and high density lipoprotein,and decreased with the increase of serum uric acid and triglyceride. |
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