| Objective:To study and further explore the curative effect and safety of Xinmailong injection on elderly patients with chronic heart failure.Xinmailong injection is used for elderly CHF patients,witch is combined with conventional western drug therapy recommend by guidelines.Methods:Selecting 133 senile patients with heart failure,are all diagnosed in the period of February 2016-October 2017,in the First Hospital Affiliated to Hebei North University.Among these people which include 73 males,60 females,are over 60 years old;the average age(73.10 + 12.54)are in line with the clinical diagnosis of heart failure(refer to Chen haozhu,Zhong Nanshan,internal medicine.The 8th edition.2013).Diagnostic criteria of hospitalized patients,and according to the NYHA classification method,whose heart function class in Ⅱ-Ⅳ.They all have a history of basic heart disease,with clinical symptoms of heart failure more than 3 months,with negative result of Xinmailong injection skin test.These patients were randomly divided into Xinmailong injection group(n = 67)and the control group or conventional therapy group(n = 66).There was no statistically significant between two groups of patients,in basic diseases and sex,used drugs ect.The control group given conventional therapy,including ACEI(angiotensin-converting enzyme inhibitors)or ARB(angiotensin II receptor blockers),beta blockers,diuretics,MRA(aldosterone receptor antagonist);On the basis of control group,the experimental group was given to Xinmailong injection(5 mg/kg)diluted to 5% glucose 250 ml intravenous injection,2 times a day.5days as a course of treatment.Before the first treatment,all patient s ahould be tested for skin allergy.Monitor before treatment and after 5 days the patient’s left ventricular ejection,the concentrion of n-terminal pro-brain natriuretic peptide(NT-pro BNP)and distance of 6 minute walking test(6 MWT),as well as cardiac function,to value the comprehensive evaluation of effectiveness of drug therapy,and at the same time observe whether cardiovascular adverse events and adverse reactions occur.Results:1.Compared with the conventional treatment group,the cardiac function classification of elderly patients with chronic heart failure could be improved significantly by adding the Xinmailong injection.2.On the basis of conventional treatment of heart failure drugs,compared with control group,experimental group significantly improved the old patients with heart failure(X2=10.224,P<0.05),and effectively reduced the level of NT-pro BNP(t=8.861,P<0.05).After a course of drug therapy,the level of left ventricular(EF)in experimental group compared with control group raised higher,statistically significant(t=2.872,P<0.05);as well as the 6 MWT(t=4.038,P<0.05).3.In the conventional therapy based on the use of Xinmailong injection,there was no significantly affect on liver function,renal work and blood K,and the difference was not statistically significant(P>0.05).4.On the basis of conventional treatment of heart failure drugs,using of Xinmailong injection does not increase adverse reactions or adverse cardiovascular events.the difference between two groups was not statistically significant(P>0.05).Conclusion:1.On the basis of conventional therapy,the combination of conventional heart failure therapy such as ACEI/ARB,MRA and diuretics,and Xinmailong injection can improve the cardiac function and the activity tolerance level of elderly patients with chronic heart failure.Moreover,these kind of improvement were better than that of the conventional treatment group.2.On the basis of the conventional treatment of heart failure drugs,the Xinmailong injection can reduce the plasma NT-pro BNP levels,and can significantly improve LVEF.3.On the basis of the conventional treatment of heart failure drugs,it is safe to use Xinmailong injection on elderly heart failure patients 。... |
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