The Research Of The Relationships Between Patent Foramen Ovale And Ischemic Stroke

Objective:In recent years,patent foramen ovale has caused the attention of people,researches found that PFO was significantly associated with ischemic stroke,which may be a potential cause,but the relationship between patent foramen ovale and stroke is still not completly clear.Through the comparison of the incidence rate of PFO and the degree of right to left shunting in the patients with acute ischemic stroke and people without stroke,the research sought to analyze the relationship between patent foramen ovale and stroke,and to reveal the clinical characters of ischemic stroke with PFO.To improve the understanding of ischemic stroke,patent foramen ovale and its relationship,provide help for the clinical diagnosis and treatment.Method:We collected patients with acute ischemic stroke and non stroke patients in the control group from 2016 January to 2018 January.The patients with acute ischemic stroke were divided into two groups,PFO(+)stroke group and PFO(-)stroke group.The patients in stroke group underwent CT scan,carotid ultrasound,and head MRI.All patients underwent TCD bubble test,and the PFO was diagnosed by TCD bubble test.General information,cerebrovascular disease risk factors,the National Institutes Of Health Stroke Scale(NIHSS)score on admission and the degree of shunting were investigated.We compared the clinical datas,the incidence rate of PFO and the degree of right to left shunting in the stroke group and control group.We also compared the neurological deficit severity,clinical outcome and cerebrovascular disease risk factors in the PFO(+)and PFO(-)stroke group.We analyzed the relationship between the degree of right to left shunting and the neurological deficit severity.Result: There was no statistically significant difference between the two groups about age and gender.PFO was more common in patients with ischemic stroke,with a statistically significant difference(44.0% VS 25.3%,p<0.05).There was no statistically significant difference among the OCSP classification groups about the incidence rate of PFO(p<0.05).There was no statistically significant difference in the incidence rate of PFO among the groups with diffrent infarcts.Medium and large shunts have significant correlation with ischemic stroke(p<0.05).The NIHSS score on admission in the PFO(+)group and PFO(-)group was not significant different(p>0.05).There was no statistically significant difference in the NIHSS score on admission among the diffrent degree of shunting groups.The incidence of the ischemic stroke risk factors(hypertension,coronary heart disease,diabetes,hyperlipidemia,hyperhomocysteinemia,atrial fibrillation and drinking history)were lower than those in the PFO(-)group,with no significant difference(p>0.05).There was no statistically significant difference between the PFO(+)and PFO(-)groups about age,gender and smoking.The incidence of carotid arteriosclerosis is significantly lower than those in the PFO(-)groups(p<0.05).The incidence of migraine is significantly higher than those in the PFO(-)groups(p<0.05).Conclusions: 1.PFO and its different degree of shunting have significant correlation with the ischemic stroke,it may be one of the risk factors of ischemic stroke.2.The ischemic stroke patients with PFO have no significant correlation with the distribution of OCSP subtypes of cerebral infarction,the distribution of infarcts,and the neurological function impairenment.