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Correlation Between Posttraumatic Stress Disorder And Blood Homocysteine,Folic Acid And Vitamin B12 In Officers And Soldiers In Xinjiang

Posted on:2019-03-03Degree:MasterType:Thesis
Country:ChinaCandidate:G Z LiFull Text:PDF
GTID:2394330566992086Subject:Clinical medicine
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Object:The investigation of soldiers stationed in Xinjiang after experiencing a traumatic event of the posttraumatic stress disorder(Post traumatics Stress disorder,PTSD)and to investigate the prevalence of PTSD in Xinjiang and traumatic stress symptoms,comorbidity of anxiety and depression,sleep status,and the characteristics of blood homocysteine,folic acid and vitamin B12 metabolism.In order to discover the mental health problems of officers and soldiers stationed in Xinjiang and early intervention.Methods:In November 2017,November 2016,356 officers and soldiers in a region of Xinjiang,which had experienced traumatic events,were investigated by an effective epidemiological survey.The survey is divided into two steps,stress disorder screening scale after trauma(PCL-C)were screened,and the scores of PCL-C positive patients,according to their clinical symptoms according to the diagnostic and Statistical Manual of mental disorders Fifth Edition(DSM-V)PTSD diagnosis standard for final diagnosis again.27 PTSD patients were screened as group PTSD,and 39 soldiers without PTSD under the same exposure were used as the control group.Using the self rating Anxiety Scale(SAS),self rating Depression Scale(SDS)were compared between the two groups with symptoms,sleep with the Athens Insomnia Scale(AIS),and the psychological stress self rating questionnaire of two groups of insomnia and recent stress situation,characteristics and detection of two groups of fasting plasma homocysteine folate and vitamin B12 levels to reflect the metabolism.The subjects were all young officers and soldiers in Xinjiang.The results of the survey were calculated using SPSS17.0 software,and analyzed by X~2 test or two independent sample t test.Results:(1)An effective epidemiological investigation was conducted on 356 officers and soldiers stationed in the Xinjiang.According to the PCL-C standard,30 soldiers were positive,the prevalence rate was 8.43%.According to the clinical manifestations,according to the DSM-V diagnostic criteria,27 cases met the PTSD criteria,and the prevalence rate was 7.58%.The coincidence rate of PTSD diagnosis between PCL-C and DSM-V was 90%(27/30).(2)PTSD group and PTSD group were young men,so the two groups in age,age,culture degree,marriage,nationality,backbone,training injury history,cadre management,to participate in recreational activities and post etc.no statistically significance.(3)Compared with non PTSD group,there were significant differences in clinical manifestation,alertness state(P<0.001),avoidance symptom(P<0.001),intruding symptom(P<0.001)and social function loss(P<0.001)between PTSD group and non PTSD group.(4)The difference in stress state(P<0.001)and insomnia(P<0.001)in the PTSD group was statistically significant compared with the non PTSD group.(5)There were statistical differences between the two groups of patients with anxiety(P<0.001)and depression(P<0.001).(6)Two groups of blood homocysteine(P=0.039),folic acid(P=0.000),vitamin B12 level(P=0.001),T3(P=0.000),T4(P=0.006)difference was statistically significant,and TSH(P=0.096),LDL(P=0.526),the difference was not statistically significant.Conclusions:(1)The prevalence of PTSD in the officers and soldiers of Xinjiang is relatively high,and the core symptoms are outstanding,accompanied by severe anxiety,depression and sleep disorders.(2)Patients with PTSD had high levels of homocysteine,low levels of folic acid and vitamin B12,and accompanied by changes in thyroid function metabolism.
Keywords/Search Tags:Post traumatic stress disorder, homocysteine, folic acid, vitamin B12, depression
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