The Risk Factor And Correlation Analysis And Fatigue And Apathy In Parkinson’s Disease

Objective:To understand the occurrence of fatigue and apathy in patients with Parkinson’s disease(PD)and to study the influence factors of the symptoms and their correlation between the two.Methods:We recruited the 66 idiopathic PD patients who visited our department of neurology,from November 2016 to November 2017 and prospectively assessed Fatigue Severity Scale(FSS)score,Modified Apathy Evaluation Scale(MAES)score.Other clinical measures including:severity of Motor symptoms,severity of PD,depression,anxiety and ability of daily living.Logistic regression analysis was used to analyze factors related to fatigue and apathy in PD,Spearman correlation analysis was used to analyze the correlation between the two.Results:1.Of the total sample,63.6% of patients with PD had fatigue,and 57.6%experienced apathy.Among them,27 cases(40.9%)fatigued PD subjects were apathetic,15 cases(22.8%)were fatigued only,and 11 cases(16.7%)were only apathetic.2.In contract,Hoehn&Yahr score,the UPDRS Part 3 score,Hamilton Depression Rating Scale(HAMD),and LDE were all significantly difference in the fatigue group(high fatigue /low apathy)than in the control group(low fatigue /low apathy)(P<0.05);Similarly,The UPDRS part3,HAMD was statistically significant(P<0.05)between apathy group(high apathy /low fatigue)and control group(low fatigue /low apathy).3.Analyses showed that the risk factors for predicting the occurrence of fatigue and apathy were UPDRS part 3(OR=2.860,95%CI 0.005~0.026)and(OR=1.064,95%CI0.060~0.473),the severity of motor symptoms is a risk factor for both.4.Correlation analysis found that there was a significant correlation between FSS average scores and AS total scores in PD(r=0.381,P<0.05).Conclusion:Fatigue and apathy are the common non-motor symptoms in Parkinson’s disease(PD),the severity of motor symptom is a common predictive factor and the two symptoms are correlation.