Analysis Of Influencing Factors Of Apathy In Patients With Parkinson’s Disease

Objective:Apathy is a common non-motor symptom of Parkinson’s disease（PD）.Due to the lack of sufficient understanding,it’s hard to identify.So early identification,timely diagnosis and treatment is particularly important.However,the influencing factors of apathy now are controversial,and there is lack of large studies on the relationship between apathy and RBD and daytime sleepiness.The purpose of this study is to explore the demographic characteristics and related risk factors of PD apathy,and to guide clinical work.Methods:Two hundred patients with PD were selected and evaluated by apathy scale（apathy scale,AS）.They were divided into apathy group and non-apathy group.All patients were statistically analyzed on general clinical data,motor symptoms score,non-motor symptoms score and medication.Results:The incidence of apathy was 69%.Univariate analysis showed that the UPDRSIII score,HY classification,HAMD score,HAMA score,RBDSQ score,ESS score,FSS score,freezing gait score,PDQ-39 score and the total levodopa equivalent dose in apathy group was higher,the course of disease in apathy group was longer（P<0.05）,while the MMSE score,Mo CA score,and education level of the apathy group were lower than those of the non-apathy group（P<0.05）,multivariate analysis showed that Hamilton Depression Scale（HDMA）,Parkinson’s Disease Quality of Life Questionnaire（PDQ-39）score,educational attainment and the total levodopa equivalent dose statistically significant.Conclusion:Apathy is a common non-motor symptom in PD patients,and it is affected by many factors.PD patients with movement disorders,cognitive impairment,depression,anxiety,RBD,lethargy,fatigue,low education level,long course of disease,poor quality of life and higher total levodopa equivalent dose are more prone to apathy.Anxiety,poor quality of life,low educational attainment and total levodopa equivalent dose were independent risk factors.