Based On Antidepressant Related Signaling Pathway Research Tongxieyaofang Relieve IBS-D Mental Mechanism Of Psychological Imbalance

Objective: Through pathway gene screening system analysis on depression pathways and genes differential expression,to explore different parts of Tongxieyaofang relieve diarrhea type irritable bowel syndrome of imbalanced mental state,if there may exist a mechanism.Methods: Choose eligible patients and voluntary to screen clinic patients with IBS-D.Take different components of Chinese medicine classic prescription of Tongxieyaofang with free decoction to observate patients’ clinical symptoms and parallel genetic testing a month later.Result: ⑴Before and after taking the drugs for patients with abdominal pain scale score,normal days defecate,depression scale score,anxiety rating scale,found different parts of Tongxieyaofang can ease diarrhea type of irritable bowel syndrome caused by abdominal pain,diarrhea,depression,anxiety,and help alleviate the discomfort of clinical symptoms;⑵Carries on the comparison to patients before and after medication mRNA,found that different parts of Tongxieyaofang have a regulating effect on mental mechanism of different pathways and mRNA content there are differences in gene expression.conclusion: ⑴ different parts of Tongxieyaofang are effective in the treatment of IBS-D components;⑵Depression,anxiety and other mental psychological factors may be one of the forming mechanism of irritable bowel syndrome;⑶Tongxieyaofang may through the mental factors of regulation so as to improve high sencetive state of visceral and relieve clinical symptoms of IBS-D depression anxiety...