The Research For The Hygroscopic Properties And Modification Technology Of Medicine Extract Powder

Chinese medicine extract powder is the main form of Chinese medicine in the preparation of intermediates.Usually the extraction solvent is water,the solid-liquid separation in the separation process based not for large-scale purification process,the extract thus prepared composition is more complex,the moisture absorption of the powder is higher.The main subject from the study is the hygroscopic properties of traditional Chinese medicine extract powder,discussesing the common factors affecting medicine extract powder hygroscopic.According to traditional Chinese medicine extract powder different hygroscopic properties,to find out suitable modification technology to improve the hygroscopic powder.Research on the impact of adding inert materials modified medicine extract powder spray the powder moisture and other properties of a dry powder preparation of learning,and establishment of Chinese medicine extract spray dried powder preparation of modified rationality evaluation process to guide the process formulation and rational use of materials,and improve the feasibility study the hygroscopic powder of film coating powder.The first part,we chose five kinds of models fitting the hygroscopic rate curve of fifty-one kinds of typical Chinese traditional medicine extract powder under the low,medium,and high humidity conditions,as evaluation index in R2,RSS,AIC value,to make the initial screening of optimum kinetic model fitting.Depending on the difference of the hygroscopic properties of powders to choose reasonable modification technology,creating dynamic equations hygroscopic powder helps to further study the relation between the surface features and the hygroscopic properties.The results show that the double exponential absorption process model can effectively simulate medicine extract powder.According to family and genus and herbal medication site,the 51 kinds of herbs are classified,then explore the common features of Chinese medicine extract powder hygroscopic.The second part,we examined the impact of mannitol,lactose,beta-cyclodextrin,dextrin,soluble starch,maltodextrin DE 11-14,gum arabic,crospovidone CL-SF on hygroscopic of the achyranthes powder,Found that the soluble starch and beta-cyclodextrin can reduce the hygroscopicity of achyranthes,and the crospovidone CL-SF can keep the original shape after hygroscopic powder.Research the influence of mixing materials on moisture and powder morphology.Chooseing modified powder to measure its surface features,to explore the characteristics associated with the powder surface moisture and moisture dynamics model parameters.Absorption kinetics studies lay the foundation for the significance of the model parameters.The third part,study the effects of film-coating of Chinese medicine extract powder on the hygroscopic powder.Comparison of spray drying and film-coating way for traditional Chinese medicine extract powder moisture absorption characteristics and the influence of powder form.The results showed that after film coating,the powder can effectively improved moisture absorption properties and maintained the inherent form of powder.Then filter the best dosage of coating materials,with the moisture absorption and morphology as index.When dosage of coating materials greater than or equal to 3%,this method can effectively reduce hygroscopic of medicine extract powder,and after hygroscopic the powder can maintain the original shape.Studying the application of this modified method,choose Radix,Radix,wolfberry,soil Fuling as a model drug,with the morphological changes after moisture absorption and moisture as an indicator,the results show that this method is feasible.