Image-guided Particle Implantation And Surgical Bi-directional Cohort Study Of Pancreatic Cancer

Purpose:To compare the efficacy of ¹²⁵I seed implantation with conventional surgical treatment of stage II and III pancreatic cancer patients and to explore differences in survival and complications between radioactive ¹²⁵I seed implantation and conventional surgery.Methods:The 83 pancreatic cancer patients who met the inclusion criteria were analyzed and divided into traditional surgical treatment（control group）and radioactive ¹²⁵I seed implantation treatment（test group）according to different treatment methods.Observe the short-term efficacy of the two groups of patients,such as postoperative complications,hospital stay,hospitalization costs,tumor markers,etc.;long-term efficacy such as survival.The statistical differences between the two groups were compared（p<0.05）.Results:The success rate of surgery was 100%in both groups,and no serious complications occurred.1Postoperative complications:The incidence of intra-abdominal hemorrhage was 3.23%（1/31）in the experimental group,3.23%（1/31）in the puncture site,and 0（0/31）in the pancreatic fistula;control group The incidence of intra-abdominal hemorrhage was 7.69%（4/52）,the incidence of biliary fistula was 11.54%（6/52）,and the incidence of pancreatic fistula was 15.38%（8/52）.The incidence of complications was significantly lower in the experimental group than in the control group.;2Hospitalization cost:The average hospitalization cost of the experimental group（31352.21±7282）yuan,and the average hospitalization cost of the control group（87001.72±17234）yuan,the difference in hospitalization costs between the two groups was statistically significant（P<0.01）3hospitalization time:the average length of stay in the experimental group was（10.00±1.89）days,the average hospital stay in the control group was（16.69±4.44）days,the median length of hospital stay in the experimental group was 10 days,and the median length of hospital stay in the control group was 15 days.There were significant differences between the two groups（P<0.01）.4 Tumor markers:The tumor markers CA19-9 in the experimental group were（199.35±294.91）umol/L,and the tumor marker CEA was（20.43±68.25）umol/L.The tumor marker CA19-9 was（251.37±376.21）umol/L,and the tumor marker CEA was（3.29±3.39）umol/L,compared with preoperative,the difference was statistically significant（P<0.05）;the test group examined blood tumor markers CA19-9 decreased（216.40±221.47）umol/L,CEA decreased(10.59±15.15 Umol/L;in the control group,the blood tumor markers CA19-9decreased（278.92±336.78）umol/L and CEA decreased（13.32±23.25）umol/L,the difference was not statistically significant（P>0.05）;5 Element:Total bilirubin was（33.27±34.49）umol/L in the experimental group at 1 month after surgery,and total bilirub in was（34.41±34.01）umol/L in the control group.The difference was statistically significant compared with that before surgery（P<0.05）;The postoperative decrease of bilirubin index in the experimental group was（46.05±46.76）umol/L,and the postoperative decrease of the bilirubin index in the control group was（38.77±59.02）umol/L,with no statistically significant differences（P>0.05）;6 Postoperative survival:The average survival time of the experimental group was（16.29±2.04）months,the median survival time was 13.3 months,and the average survival time of the control group was（19.31±1.71）months.The median survival time was15.3 months.There was no significant difference between the two groups（P>0.05）.