| Objectives:1、The connection between breast cancer and thyroid cancer is still controversial,this study aims to explore the correlation between TC and BC,providing evidence for the common basis mechanisms of TC and BC;2、As the double primary cancer with breast and thyroid are increasing,it brings about a huge psychological and economic burden happened to patients and their families,this study aims to find out risk factors of the double primary cancer with breast and thyroid,which guides the prevention and treatment for the double primary cancer with breast and thyroid.Methods:1、6597 patients with thyroid neoplasm from January 1st,2012 to December 31st,2016 in our department,diagnosed with thyroid cancer patients 3184 cases,it were divided into two groups by whether have history of breast cancer or not.Among them,60 cases of thyroid cancer with history of breast cancer,3124 cases of thyroid cancer without history of breast cance.Statistical software SPSS 22.0 was used to compare the incidence of thyroid cancer in the history of breast cancer with no history of breast cancer,and P<0.05 was considered statistically significant.2、12028 patients with Breast neoplasm from January 1st,2012 to December 31 st,2016 in our hospital,diagnosed with Breast cancer patients 5917 cases(49.19%),it were divided into two groups whether have history of thyroid cancer or not.Among them,0 cases of breast cancer with history of thyroid cancer,5917 cases of breast cancer without history of thyroid cance.Compare with the composition of the two groups.3、Collectting 5917 cases of patients diagnosed with breast cancer from 2012.1.1-2016.12.31 in our hospital,among which 93 were found secondary primary malignant tumors following breast cancer,in it,thyroid carcinoma were 60 cases(64%),10 cases of pulmonary malignant tumor(11%),cervical cancer 7 cases(8%),3 cases of ovarian cancer(3%),melanoma in 3 patients(3%),2 cases of endometrial carcinoma(2%),other nasopharyngeal carcinoma,liver cancer,malignant bone tumor,colon cancer,ureteral malignant tumors and malignant pleural mesothelioma,brain cancer,leukemia,each 1 case.Comparing the composition of thyroid cancer with the other types of malignancy following breast cancer.4、Due to the double cancer cases collected all for thyroid cancer following breast carcinoma group,so selecting thyroid carcinoma following breast cancer 60 cases as the study group,in the same period were randomly selected single 60 cases of breast cancer as control group,and to study the dangerous factors of double primary cancer thyroid carcinoma and breast cancer.Statistical software SPSS 22.0 was used to study age,BMI(Body mass index,BMI),T3,T4,TSH,Tg-Ab,the expression of Estrogen receptor(Estrogen receptor,ER)and Progesterone receptor,Progesterone receptor(PR)and the Her-2 analysis indicators were used for single factor and multiple factors analysis.The median age and BMI were meaning plus or minus standard deviation(x plus or minus s).T3,T4,Tg-Ab and TSH were significantly different in individual patients,and were not subject to normal distribution,and analyzed their differences with rank and test.ER,PR,Her-2;P<0.05 was considered to be statistically significant.Logistic regression was used for multivariate analysis.5、The 60 cases of thyroid and mammary double primary cancer treated by our hospital from January 1st,2012 to December 31st,were selected as the study group,and 60 cases of single thyroid cancer were treated as control group in the same period.The SPSS 22.0 software was used for statistical analysis to compare with the diameter,lymph node metastasis,and external metastasis of thyroid tumors in the two groups,and the measurement data was expressed as mean value plus or minus standard deviation(x plus or minus s),and t-test was used.Counting data tested by χ2;P<0.05 was considered to be statistically significant.Results:1、The incidence of thyroid cancer in breast cancer group was higher than that in non-breast cancer group,and the difference was statistically significant,It showed that the incidence of thyroid cancer in patients with breast cancer history was higher than that of non-breast cancer.Thyroid carcinoma following breast cancer were 60 cases(64%),were significantly higher than those of other malignant tumors.The proportion of breast cancer(5917/12028)without the history of thyroid cancer was significantly greater than that with the history of thyroid cancer(0/73).We speculate that thyroid cancer may not be related to breast cancer.2、Single factor analysis shows that thyroid cancer after breast cancer was significantly correlated with T3、ER and her-2 positive expression,with statistical differences;Multifactor analysis of breast and thyroid double primary cancer is related to HER2 receptor positive,serum T3(OR=2.930(1.234-6.960),P=0.015;OR=19.085(2.911-125.117),P=0.002).3、Breast cancer recurrence thyroid carcinoma and thyroid carcinoma group there was no statistically significant difference on tumor diameter(P = 0.2),lymph node metastasis(P = 0.255)between the two groups(P = 0.104),multiple lesions,gland metastasis(P = 0.209)distribution in patients with no statistical difference.Conclusions:1、Breast cancer is associated with the risk of thyroid cancer and cannot be fully monitored.We suggest that if patients with a history of breast cancer are diagnosed with thyroid neoplasm,they should be more active to deal with it.despite the thyroid neoplasm by shown for benignning or too small with preoperative ultrasound or palpation inspection,vigilance should not be given up,it is very important to strengthen the follow-up.2、T3 and Her-2 are independent risk factors in the incidence of breast and thyroid double primary cancer.ER is related to the incidence of double primary cancer,but it is not an independent risk factor.3、Comparing thyroid carcinoma following breast cancer with single thyroid cancer clinical pathological features no significant statistical difference,so the treatment of thyroid carcinoma following breast cancer shouldn’t be radical. |
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