To Explore The Correlation Of Atherosclerosis Between Coronary And Head-Neck Artery Based On Dual-source CT

Objective:Both the blood vessels in the heart and head-neck can produce atherosclerosis,which can be life-threaten ing when the lesion is severe.This article explores the risk factors that may aggravate vascular disease,and uses dual-source CT to evaluate the severity of coronary,intracranial and extracranial atherosclerotic stenosis,and further study the correlation between the two.These help to prevent and detect the occurrence of cardiovascular and cerebrovascular diseases in a timely manner,and reduce the losses caused by diseases to humans and society.Materials and methods:137 patients with suspected or confirmed Cardiovascular and cerebrovascular atherosclerotic disease in the first affiliated hospital of Dalin medical university were enrolled from March 2015 to November 2018,including 77males and 60 females,aged 30-90 years,mean age(65.58±11.45)years.All patients enrolled in the study were required to complete the DSCT of coronary and head and carotid arteries,or to complete two examinations within two weeks.The results were based on coronary DSCT results.group A was defined as coronary stenosis<50%(80cases,43 males,37 females),group B was defined as coronary stenosis?50%(57cases,34 males,23 females).The degree of intracranial and extracranial stenosis was classified into three grades according to DSCT results:Mild stenosis(0 to 29%),moderate stenosis(30%to 69%),and severe stenosis to complete occlusion(70%to100%).On admission,the general clinical data that should be recorded in detail are gender,age,heart disease,high blood pressure,diabetes,cerebral infarction,atrial fibrillation,family history,smoking and drinking history,etc.On the second day of admission,patients enrolled in the group were required to receive blood tests for blood routine,biochemical liver function,creatinine,uric acid and serum homocysteine.The experimental data were analyzed using the SPSS 21.0 statistical software package.Mean±standard deviation indicates measurement data,independent sample t test was used to compare differences between groups,x~2 test was used to compare count data,and coronary artery and intracranial and extracranial artery stenosis were correlated using Spearman rank analysis,Multivariate logistic regression analysis was performed for univariate analysis with statistically significant differences.P<0.05 was considered statistically significant.Results:(1)Baseline data comparison showed that the degree of coronary artery stenosis(group B)was significantly different from that of the groupA in age,HDL-C,and smoking history(P<0.05).However,there were no statistically significant differences in hypertension,gender,diabetes,drinking history,gender,TG,TC,LDL-C,HCY,UA,and CR.Prompt age,HDL-C,smoking history can increase the extent of coronary artery stenosis.(2)According to the DSCT results of coronary artery and intracranial and extracranial arteries,there was a significant difference between the degree of coronary artery stenosis and the degree of extracranial artery stenosis(P<0.05),and Spearman rank correlation coefficient(R=0.478,P<0.001),indicating a positive correlation between the two.There was also a significant difference between the degree of coronary artery stenosis and intracranial artery stenosis(P<0.05),and Spearman correlation coefficient(R=0.396,P<0.001),indicating a positive correlation between them.(3)Risk factors associated with coronary artery disease,hypertension,diabetes,smoking history,drinking history,age,and blood lipids were included in one-way regression analysis.Age,smoking history,HDL-C,degree of intracranial artery stenosis,and extracranial stenosis were found.The degree of significance was significantly different(P<0.05),and it was brought into multivariate Logisitic regression analysis.The age(OR=1.053,95%CI 1.013-1.95,P=0.009)and the degree of extracranial artery stenosis(OR=4.074,95%CI 2.156-7.698,P<0.001)was an independent risk factor for aggravating coronary lesions.Conclusions:(1)DSCT plays an important role in the evaluation of coronary artery,intracranial and extracranial atherosclerotic lesions.(2)Coronary atherosclerosis has a certain correlation with intracranial and extracranial atherosclerosis.(3)The degree of coronary artery narrowness was positively correlated with the degree of intracranial and extracranial arterial stenosis.The degree of intracranial and extracranial arterial stenosis increased with the severity of coronary stenosis.(4)Age,drinking history,intracranial and extracranial artery stenosis are risk factors for aggravating coronary artery disease,while age and degree of extracranial artery stenosis are independent risk factors for aggravating coronary artery disease.