| Objection:Comparing the efficiency of low temperature plasma radiofrequency ablation on glottic and supraglottic laryngeal carcinoma,discussing whether combined radiotherapy after radiofrequency ablation of laryngeal carcinoma is needed,and analyzing the possible factors related to local recurrence and excessive proliferation of granulation tissue in operation area after low temperature plasma operation of laryngeal carcinoma.In order to provide certain reference basis for low temperature plasma radiofrequency ablation on laryngeal cancer.Methods:Retrospective analysis of 51 patients of glottic and supraglottic squamous cell carcinoma who treated with low temperature plasma radiofrequency ablation from May2016 to May 2018 at the Department of Otolaryngology of Second Affiliated Hospital of Dalian Medical University,including 43 cases of glottic carcinoma(37 cases T1,3cases T2 and 3 cases T3),8 cases of supraglottic carcinoma(all cases are epiglottis carcinoma,6 cases T1 and 2 cases T2).None of the cases had cervical lymph node metastasis or distant metastasis(c N0M0),All the low-temperature plasma radiofrequency ablations were performed by the same professor in our department.The data of the inpatient medical record and postoperative follow-up through regular laryngoscopy or phone calls was collected.The follow-up period ranged from 6 months to 30 months(initial time is the date of low temperature plasma radiofrequency ablation,up to May 2018 or the date of recurrence),with a median of 16 months.Local recurrence occurred in 3 cases of glottic carcinoma(2 cases T1 and 1 cases T3),and 5 cases of supraglottic carcinoma(4 cases T1 and 1 cases T2).Patients with local recurrence have been effectively controlled after radiotherapy and have survived till now.SPSS13.0 statistical software was used for statistical analysis of all data.The life table,Kaplan-Meier and partial correlation in SPSS13.0 statistical software were used for statistical analysis.Calculating respectively the local control rate of glottic carcinoma in early stage(including T1,T2),T3 and early supraglottic carcinoma.Comparing respectively the local recurrence risk of early glottic carcinoma and early supraglottic carcinoma and glottic carcinoma T3 stage.Analyzing the correlation between gender,smoking,alcohol consumption,pathological grade,laryngeal carcinoma classification and local recurrence after low temperature plasma surgery for laryngeal carcinoma.Analyzing the correlation between hyperplasia of granulation tissue and hypertension and diabetes in patients with T1 glottic carcinoma.Test criteria:P<0.05 indicated significant difference;r>0 indicated positive correlation,r<0 indicated negative correlation,and the degree of correlation was evaluated according to the size of R value.Results:1.The local recurrence risk of early glottic and early supraglottic carcinoma was significantly different(P = 0),but there was no significant difference between early and T3 glottic carcinoma in local recurrence risk(P = 0.095)。2.The correlation between local recurrence and laryngeal carcinoma classification after laryngectomy is statistically significant(P<0.05,r=0.626),but there was no significant difference between gender,smoking,alcohol consumption and pathological grade(P >0.05).3.There was no significant correlation between hyperplasia of granulation tissue and hypertension or diabetes in patients with T1 glottic carcinoma after plasma resection(P > 0.05).Conclusion:1.Low temperature plasma radiofrequency ablation is effective in the treatment ofstage T1,T2 and T3 glottic laryngeal carcinoma,postoperative radiotherapy is not required.2.The local recurrence risk of early supraglottic laryngeal carcinoma is significantly higher than that of early glottic carcinoma,combined radiotherapy should be considered after operation.3.The cause of granulation tissue proliferation after low temperature plasma radiofrequency ablation is unknown,further research is needed. |
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