Discussion On The Rationality Of Pressure Bandaging Combined With Ice Compress In The Treatment Of Acute Soft Tissue Injury

ObjectiveTaking the model of acute skeletal muscle injury as the research object,we observed the treatment effect of compression bandaging alone and compression bandaging combined with ice compress and the change of TGF-beta 1(transforming growth factor-beta 1)content in the injured area.Analyzed the possible mechanism behind the control group,and explored whether there was an "invalid part" in the principle of treating acute soft tissue injury(RICE).MethodTwenty-four adult New Zealand rabbits were randomly divided into three groups: model group,compression bandage group,compression bandage with ice compress group.There were 8 rabbits in each group.The model group was not treated;pressure bandaging was performed immediately after the completion of the model;pressure bandaging with ice compress group,immediately after the completion of the model,pressure bandaging and ice compress treatment.Two animals were sampled at three time points of 1,2 and 3 days after modeling to measure limb dimension,and then sampled in the labeled muscle area.The content of TGF-beta 1 was detected by immunohistochemical method.On the 14 th day,the same method was used to observe the changes of muscle fibers by eosin-hematoxylin(HE)staining.ResearchThe swelling value of injured limbs: 1 day,2 days and 3 days after injury,the swelling degree of the compression bandage group and the compression bandage with ice compress group was less than that of the model group(P < 0.05),and there was no significant difference between the compression bandage group and the compression bandage with ice compress group(P > 0.05).Immunohistochemical detection of the expression of TGF-beta 1: 1 day after injury,there was no significant difference in the surface level between groups(P > 0.05).There was no significant difference in the expression of TGF-beta-1 between the compression bandaging group and the model group on the 2nd and 3rd day after injury(P > 0.05).The expression of TGF-beta-1 in the compression bandaging with ice compress group was lower than that in the model group and the compression bandaging group(P < 0.05).Histological score: 14 days after injury,the histological score of pressure bandage group and pressure bandage with ice compress group was better than that of model group,with significant difference(P < 0.05).There was no significant difference in histological score between compression bandage group and compression bandage with ice compress group(P > 0.05).Conclusion1.There was no significant difference in the degree of swelling control and injury recovery between "compression bandage" and "compression bandage combined with ice compress" in the treatment of acute soft tissue injury.2.Ice dressing after compression bandaging inhibits the expression of TGF-beta 1 in the early stage of injury.If "pressure bandaging" has been carried out,no further use of "ice pack" is required.