Study On The Correlation Between Homocysteine Level And Coronary Heart Disease

Objective: To investigate the relationship between serum homocysteine level and coronary artery disease and left ventricular function in patients with coronary heart disease.Methods: A total of 228 patients with coronary heart disease diagnosed in our hospital from August 2015 to August 2017.8 were collected.According to the level of plasma homocysteine,the patients are divided into two groups,84 patients in the high Hcy group(Hcy > 15umlo/L)and 142 patients in the normal Hcy group(Hcy ?15umol/L),and All patients were required to complete coronary angiography.Results: The incidence of acute coronary syndrome and Gensini score in Hcy group were higher than those in normal Hcy group(97.6% vs 85.9%?26.90±19.55 vs41.46±27.75,all P<0.05).The proportion of stable angina pectoris higher in normal Hcy group than that in hight Hcy group(14.08% vs 2.38%),There was no significant difference in the proportion of single and multi-vessel lesions between the two groups.(38.09% vs 36.61%,61.90% vs 62.67%,P>0.05).There was no significant difference in homocysteine level between single vessel coronary artery disease group and multi-vessel lesion group(14.245 ±8.06 vs 14.32 ±5.39,P > 0.05).The level of Hcy in acute coronary syndrome group was significantly higher than that in Stable angina pectoris group(14.78 ± 5.44umol/L vs 11.22 ± 3.48umol/L,P < 0.05).The results of correlation analysis between homocysteine and Gensini score showed that Gensini score increased with the gradual increase of homocysteine(r=0.370,y=8.77+1.6x,P <0.05).There were significant differences in left ventricular mass index,left ventricular ejection fraction and B-type natriuretic peptide between hyperhomocysteinized group and normal homocysteinized group(118.42 ±24.58g/m2 vs 108.76 ±25.12 g / m2,P <0.05),and there were significant differences in left ventricular mass index(LVMI),left ventricular ejection fraction(LVEF)and type B natriuretic peptide(P < 0.05).54.89±6.79% vs 57.16 ±4.13%,191.37 ±342.90 vs 117.20 ±18.56,P < 342.90).The left ventricular mass index and B-type natriuretic peptide in the hyperhomocysteinized group were significantly higher than those in the normal homocysteinized group,and the left ventricular ejection fraction was significantly lower than that in the normal Hcy group.There was no significant difference in Relative wall thickness of left ventricle?Ratio of peak E to peak A in early and late diastolic maximum blood flow velocity?Ratio of peak E peak of early and late diastolic maximum flow velocity to early diastolic e' of mitral valve?deceleration time of E wave.(0.43 ±0.06 vs 0.42 ±0.07,0.82±0.28 vs 0.95 ±0.74,9.91 ±3.57 vs 9.53 ±0.53).3.52201.73 ±56.72 vs207.28 ±49.69,P > 0.05)Conclusion: 1.In patients with coronary heart disease,the prevalence of acute coronary syndrome in hyperhomocysteingroup was significantly higher than that in normal homocysteingroup,and the plasma homocysteinconcentration in acute coronary syndrome group was significantly higher than that in stable angina pectoris group.It issuggested that the level of homocysteine may be related to the stability of coronary artery plaques.2.The Gensini score of hyperhomocysteinemia group was significantly higher than that of normal homocysteingroup,and linear regression showed that Gensini score increased gradually with the increase of homocysteinemia,suggesting that hyperhomocysteinemia was positively correlated with the degree of coronary artery disease.3.In patients with coronary heart disease,the degree of systolic dysfunction in hyperhomocysteingroup was higher than that in normal homocysteingroup.