Function And Mechanism Of Mindin-CD11b/CD18 Axis During Colitis Model And IBD Immunopathogenesis

Background and Aims:Inflammatory bowel disease(IBD)is an idiopathic inflammatory bowel disease involving the ileum,rectum and colon.It includes ulcerative colitis(UC)and crohn's disease(CD).UC is a continuous inflammation of the colonic mucosa and submucosa.The disease usually involves the rectum first and gradually spreads to the whole colon.CD can involve the whole digestive tract and is a discontinuous full-layer inflammation.The etiology and pathogenesis have not been fully defined.It is kno-wn that inflammatory responses caused by abnormal intestinal mucosal immune system responses play an important role in the pathogenesis of IBD,which is believed to be caused by the interaction of multiple factors,including environmental,genetic,infectious and immune factors.Methods and results:ECM protein Mindin,can directly recognize antigens on the surface of bacteria,which plays an important role in innate and acquired immunity.Integrins are the major family of cell surface receptors that mediate cell-to-cell and cell-to-extracellular matrix interactions.CD11b/CD18 is a member of the ?2 subfamily of the integrin family and is present on the surface of most leukocytes.When combined with ligands,CDllb/CD18 can mediate leukocyte aggregation,adhesion and signal transduction,and play an important role in the recognition and clearance of target cells or pathogenic microorganisms by leukocytes.Conclusion:We confirmed in vitro that mindin and CDl11/CD18 constitute a ligand receptor axis,which promotes chemotaxis and phagocytosis of macrophages.Through the establishment of mouse enteritis model,we found that the ligand receptor axis composed of mindin and CDllb/CD18 worked together to promote the occurrence and development of enteritis.These results suggest that Mindin may be a new molecular target for the treatment of IBD.