Effect Evaluation Of Vitamin D Drops In Children With Asthma

PurposeVitamin D(VD)has immunomodulatory effects and has a regulatory role in the development of asthma.In this study,the experimental group was treated with conventional aerosolized budesonide supplemented with vitamin D drops and the control group was treated with conventional nebulized budesonide to treat asthma.The number of asthma attacks in the two groups was compared.Vitamin D drops were added as adjuvant therapy for asthma.Effectiveness and safety are instructive for clinical treatment.MethodsPatients with bronchial asthma who were admitted to the pediatric department of the Affiliated Central Hospital of Shenyang Medical College from October 2017 to November 2018 were enrolled.Serum vitamin D levels were measured and clinical data were collected and recorded,including:family history of asthma,sun exposure,Daily activities and history of eczema.A total of 120 children with serum vitamin D levels below normal levels were included in the study(inclusion criteria:diagnostic criteria for children with asthma;ages 3-6 years;asthma in acute phase.Exclusion criteria:respiratory failure and heart rate)Severe asthmatic children with exhaustion;congenital heart and lung disease,cardiac insufficiency,etc.;exclusion of wheezing caused by foreign bodies or other causes;exclusion of abnormal calcium and phosphorus metabolism and chronic kidney disease;the child has not taken immunization for nearly 2 months The history of modulators and vitamin D preparations.),including 59 males and 61 females,aged 3-6 years,mean(4.62 ± 1.01)years old.According to whether the children took vitamin D drops,the subjects were divided into two groups,60 in the experimental group and 60 in the control group.Among them,according to the Global Initiative for Asthma(GINA)program,the experimental group was given oral vitamin D drops(2000 IU/time,once a day,oral for 1 month)combined with budesonide atomization treatment,each Periodically,the serum VD level of the child is tested regularly.If the serum VD level is normal,the amount of vitamin D drops is changed(400 IU/time,once a day,orally for 1 month),if the blood VD level is still lower than the normal value.Continue to take oral vitamin D drops,and record the number of asthma attacks in children according to the asthma control test score;the control group was treated with budesonide according to the GINA protocol,and the VD level was measured every month and recorded according to the asthma control test score.The number of asthma attacks in children.Both groups were followed up for 3 months.Excluding the number of cases of late loss of follow-up,the data were analyzed by SPSS statistical software.ResultExcluding the children who were lost to follow-up,there were 110 children with bronchial asthma in the experimental group and the control group;the age of the experimental group was(4.62±0.99)years,and the age of the control group was(4.55± 1.03).There was no significant difference between the two groups(t =0.377,p=0.707).In the experimental group,28 boys and 27 girls;25 males and 30 females in the control group,and there was no significant difference in gender between the two groups(t=0.568,p=0.571).Serum vitamin D levels(15.77 ± 2.74)ng/ml in the experimental group before treatment,serum vitamin D levels(1 6.52±2.58)ng/ml in the control group before treatment,there was no significant difference in serum vitamin D levels between the two groups(t=-1.49,p=0.1 39).The results of univariate analysis of bronchial asthma showed that the clinical data including family history of asthma,sun exposure,daily activities,and history of eczema were compared.There was no significant difference between the two groups(P>0.05).Logistic regression analysis of risk factors showed that vitamin D levels were a high risk factor for asthma attacks.The experimental group was followed up for the first month of asthma attack(1.13±0.61)times,and the control group was followed up for the first month of asthma attack(1.56±0.66)times.The difference between the two groups was statistically significant(t=-3.60,p=0.001).The experimental group was followed up for the second month of asthma attack(0.69±0.61)times,and the control group was followed up for the second month of asthma attack(1,33±0.58)times.The difference between the two groups was statistically significant(t=-5.63,p=0.000).The experimental group was followed up for 3 months(0.31±0.47),and the control group was followed up for 3 months(1.09±0.52).The difference was statistically significant(t=-8.31,p=0.000).Conclusion1.The number of asthma attacks in the two groups was not related to age and gender.2.Family history of asthma,sun exposure,activity and history of eczema are not high risk factors for asthma attacks.Serum VD levels are risk factors for asthma attacks in children with bronchial asthma.3.In the experimental group,the vitamin D drops were compared with the control group.The budesonide aerosol treatment group was observed at 1 month,2 months,and 3 months.The number of asthma attacks and the level of VD were observed.A negative correlation,that is,the lower the serum VD level,the more the number of wheezing episodes.4.Appropriate vitamin D drops in children with bronchial asthma can reduce the onset of asthma,which will benefit children’s healthy growth and benefit families and society.