| Objective:Through the observation of the improvement of TCM syndrome score,the dynamic changes of serological indicators β-HCG,P,E2,PAPP-A,and the development of pelvic B-modc ultrasound embryos before and after the treatment of Early Threatened Abortion of spleen and kidney deficiency type with Hutaiyin combined with Dydrogesterone tablets,and follow-up of pregnancy outcomes to objectively study the clinical treatment of Early Threatened Abortion of-spleen and kidney deficiency type with Hutaiyin combined with Dydrogesterone tablets Effectiveness and influence on pregnancy outcome.Methods:April 2017 to January 2019 to hospital of patients with Ear-ly Threatened Abortion with deficiency of spleen and kidney in 60 cases.The patients were randomly divided into treatment group(30 cases)and control group(30 cases).The treatment group was given Hutaiyin+ Dydrogesterone tablets orally,while the control group was given Dydrogesterone tablets orally for a course of treatment(2 weeks).Follow up and fill in the clinical symptoms observation form bef-ore and after treatment in two groups.Record the serological indicators of β-HCG,P,E2 and PAPP-A levels and the development of pelvic B-mode ultrasonography embryos.Follow up pregnancy outcomes.The data were processed and analyzed by software IBM SPSS20.0 to explore the correlation between serum PAPP-A and serological indicators β-HCG,P,E2,and to evaluate the clinical efficacy of Hutaiyin combined with Dydrogesterone tablets in the treatment of Early Threatened Abortion with spleen and kidney deficiency and its influence on pregnancy outcome.Results:(1)Basic data:Before treatment,there was no significant difference in age,menopausal days,number of abortions,severity of disease,serological indicators of β-HCG,P,E2 and PAPP-A between the two groups(P>0.05).(2)Symptom score:The symptoms score of the two groups after treatment was significantly lower than that before treatment(P<0.05),and that of the treatment group was significantly lower than that of the control group(P<0.01).It is suggested that the combination of Hutaiyin and Dydrogesterone tablets can significantly improve the clinical symptoms of threatened abortion.(3)Clinical efficacy:The total effective rate of the treatment group was 96.7%,and that of the control group was 90.0%.The total effective rate of the treatment group was significantly better than that of the control group(P<0.05).It is suggested that the combination of Hutaiyin and Dydrogesterone tablets can improve the effective rate of threatened abortion(4)Inlluenccs on serologictal indicators:Serum levels of β-HCG,P,C2 and PAPP-A in both groups increased after treatment(P<0.05),but there was no significant difference in serum P levels between the two groups after treatment(P>0.05).The rising trend of serum levels ofβ-HCG,E2 and PAPP-A in the treatment group was more significant than that in the control group(P<0.05).It is suggestced that the combination of Hutaiyin and Dydrogesterone tablets can increase the levels of serum β-HCG,E2 and PAPP-A(5)Index correlation:Wilson correlation analysis showed that serum E2 was positively correlated with PAPP-A(P=0.019<0.05 in treatment group and P=0.037<0.05 in control group).There was no significant correlation between serum β-HCG and PAPP-A(P=0.006<0.05 in treatment group and P = 0.365>0.05 in control group).There was no significant correlation between serum P and PAPP-A(P 0.104>0.05 in treatment group and P = 0.530>0.05 in control group)(6)Pregnancy outcomes:The incidence of adverse pregnancy outcomes in the treatment group was 4.5%,while that in the control group was 26.1%.The incidence of adverse pregnancy outcomes in the treatment group was significantly lower than that in the control group(P<0.05).It shows that the combination of fetal protection drink and Dydrogesterone tablets can improve the pregnancy outcome of threatened abortion.(7)Adverse reactions:There were no significant adverse reactions and no abnormal safety indicators in both groups during treatment.It is safe and reliable to treat this disease with Hutaiyin combined with Dydrogesterone tablets.Conclusion:Hutaiyin combined with Dydrogesterone tablets has definite clinical effect in Treating Early Threatened Abortion of spleen and kidney deficiency type,without obvious toxicity and side effects.Compared with the treatment of Dydrogesterone tablets alone,it can significantly improve clinical symptoms,increase the levels o f serum β-HCG,E2 and PAPP-A,significantly increase the rate of fetal protection and improve pregnancy outcomes.Serum E2 is positively correlated with PAPP-A,while serum β-HCG,P and PAPP-A have no significant correlation. |
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