| BackgroundLaryngopharyngeal reflux disease(LPRD),also called the reflux pharyngitis.In the aspect of the etiology,clinical manifestations/signs and treatment,which is different from the chronic sore throat and the gastroesophageal reflux disease in the general sense.The treatment of western medicine for LPRD has diagnosis,long treatment cycle and recrudescence problem etc,but great progress has been made in the researcher into the etiology,pathogenesis and treatment of LPRD from the perspective of traditional Chinese medicine.In terms of syndrome differentiation and treatment,doctors achieved a desirable therapeutic effect who used the banxia houpu soup to treat LPRD featured by Qi depression and phlegm obstruction.Therefore,it is an effective approach to explore the combination of Chinese and western medicine in the treatment of LPRD featured by Qi depression and phlegm obstruction.ObjectiveObjective to evaluate the clinical efficacy of Banxia Houpu soup combined with proton pump inhibitors in the treatment of laryngopharyngeal reflux disease featured by Qi depression and phlegm obstruction,and to explore the mechanism of Banxia Houpu soup.Method1.In this study,from January 2014 to March 2018,112 patients in Xinxiang First People's Hospital with LPRD featured by Qi depression and phlegm obstruction were randomly divided into control group and observation group,56 cases in each group.There were no significant differences in age,sex,course of disease,RSI score,RFS score and TCM symptom score between the two groups.The baseline condition was good,and the data of the two groups were comparable(P>0.05).2.Health guidance was given to 112 patients with LPRD featured by Qi depression and phlegm obstruction to change their unhealthy lifestyle and dietary habits.The control group was treated with omeprazole enteric-coated capsules combined with domperidone tablets,while the observation group was treated with Banxia Houpu Decoction on the basis of the treatment plan of the control group.Both groups were treated for 4 weeks,during which patients were advised not to take other drugs that might affect the therapeutic effect.Four weeks later,the RSI,RSF and TCM symptoms scale were re-evaluated,and fiberolaryngoscopy was performed before and after treatment.Liver and kidney function and electrocardiogram were examined before and after treatment,and adverse drug reactions were monitored.Therapeutic evaluation refers to Expert Consensus on Diagnosis and Treatment of Pharyngeal and Laryngeal Reflux Diseases(2015)and Guiding Principles for Clinical Research of New Chinese Medicine.3.Therapeutic evaluation references?Expert Consensus on Diagnosis and Treatment of Pharyngeal and Laryngeal Reflux Diseases(2015)?and?Guiding Principles for Clinical Research of New Chinese Medicine?.4.Statistical processing:SPSS 21.0 was used for data processing.The counting data were expressed as percentages,and the differences among groups were compared.All data were tested for normality.Measuring data were expressed as x±s,t test was used for comparison between the two groups,and x~2 test or Fisher's exact test was used for counting data.Taking a=0.05 as the test standard,P<0.05 has statistical significance.Result1.Evaluation of clinical symptoms of Western medicine:The total effective rate of the observation group was 96.5%,and that of the control group was 73.2%.There was a significant difference between the two groups(P<0.05).2.Evaluation of TCM symptoms:The total effective rate of the observation group was 96.4%,and that of the control group was 76.8%.There was significant difference between the two groups(P<0.05).3.Compared before and after treatment,the total RSI score of the observation group and the control group decreased significantly after treatment(P<0.05);the total RSI score of the observation group was lower than that of the control group before and after treatment(P<0.05);the total score of the observation group was lower than that of the control group in irritating cough,supine cough,pharynx and throat mucus,reflux and total score(P<0.05).4.Compared before and after treatment,the total score of RFS in the observation group and the control group was lower than that before treatment(P<0.05),and the difference between the two groups was significant(P<0.05).Compared before and after treatment,the total score of RFS in the observation group was lower than that in the control group(P<0.05).5.Compared before and after treatment,the total score of TCM symptoms in the observation group and the control group was lower than that before treatment(P<0.05),and the difference between the two groups was significant(P<0.05).Compared before and after treatment,the total score of TCM symptoms in the observation group was lower than that in the control group(P<0.05).6.No drug allergic reaction was found in both groups.Two adverse reactions occurred in the control group,all of which were mild.Four adverse reactions occurred in the observation group,all of which were mild.Fisher's exact test showed that the P value between the two groups was 0.679,and there was no significant difference between the two groups(P>0.05).ConclusionLoading Banxia Houpu soup can improve the curative effect of proton pump inhibitors combined with gastric motility drugs on LPRD featured by Qi depression and phlegm obstruction.It can effectively improve the symptoms of irritating cough,supine cough,pharynx and larynx mucus,reflux and other symptoms.It can obviously relieve the patients'pseudovocal fold,granuloma,vocal cord edema,laryngeal mucus accumulation,erythema/congestion and other physical signs.Banxia Houpu Decoction combined with proton pump inhibitors and gastric motility drugs has high safety and tolerable adverse reactions. |
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