| Purpose:1.To observe the clinical progress of yangxin decoction(yxd)in treating chronic heart failure combined with ventricular premature beat due to qi and blood deficiency in our hospital.2.By observing the TCM symptoms and 6-minute walking test results of yangxin decoction for chronic heart failure with qi-blood deficiency combined with ventricular premature beat before and after treatment,and the changes of left ventricular ejection fraction,BNP,ventricular premature frequency,quality of life score and other indicators,the clinical treatment effect was explored.Method:A total of 72 patients with chronic heart failure(qi-blood deficiency type)combined with ventricular premature beat were selected.The patients were aged between 18 and 85 years old,with no gender restriction between men and women.The patients were randomly divided into experimental group and control group with 36 cases in each group.All patients with western medicine standardized treatment(ACEI/ARB,diuretics,beta-blockers,aldosterone antagonists,),treatment group given standardized treatment of western medicine plus yangxin soup taste(Fried juice 300 ml water,150 ml each time,2times,morning and evening suit),control group were given western medicine standardized treatment plus and shensong yangxin capsule(ridge pharmaceutical co.,LTD.(Beijing,0.4g/grain,a 2-4,day 3,oral).At the same time,patients with other complications can be given corresponding drugs.The course of treatment was 4 weeks in total.Lee’s score,6-minute walking test,cardiac ultrasound,serological index,ventricular early frequency index of dynamic electrocardiogram,TCM syndrome single score and quality of life score before and after treatment were observed in both groups.Statistical analysis was conducted by means of X2 test and t test.Result:1.Comparison of general data between the experimental group and the control groupshowed that there was no significant difference in basic data between the two groups,with comparability in gender,age and disease course(P > 0.05).2.The scores and severity of main symptoms and secondary symptoms of TCM were statistically analyzed,and the results showed that there was no significant difference in TCM symptom scores between the two groups before treatment(p>0.05),which was comparable.The improvement effect of TCM symptoms in the experimental group was better than that in the control group after treatment(p<0.05).3.There was no statistically significant difference in Lee’s integral between the two groups before treatment(p>0.05),and the two groups were comparable.After treatment,scores in both groups were significantly improved,and scores in the experimental group were significantly lower than those in the control group(p<0.05).4.Before treatment,a 6-minute walk experiment was conducted between the control group and the experimental group,and the comparison showed that there was comparability between the two groups(p>0.05).There was significant improvement after treatment,but no statistical difference was found between the two groups(p>0.05).5.There was no significant difference in LVEF between the experimental group and the control group before treatment(p>0.05).After treatment,the total effective rate of the experimental group was 83.3%,and that of the control group was 75.0%,indicating that the experimental group was superior to the control group in improving patients’ LVEF.However,the chi-square test showed that the difference between the two groups was not statistically significant,p>0.05.6.Before treatment,the levels of NT-ProBNP in the control group and the experimental group were comparable(p>0.05).After treatment,both groups showed significant improvement.But there was no significant difference between the two groups.7.Before treatment,there was no significant difference in the frequency of PVCS between the two groups,which was comparable(p>0.05).After treatment,both groups showed significant improvement compared with before treatment.But there was no significant difference between the two groups.8.Before treatment,all TCM symptoms were comparable between the two groups(p>0.05);After treatment,the main symptoms of the two groups were compared between the two groups(p<0.05),suggesting statistically significant differences between the two groups.The results showed that palpitation,chest tightness,shortness of breath,fatigue and fatigue were significantly lower in the experimental group than the control group,that is,the improvement of the experimental group was better than the control group.9.Before treatment,the qol scores of the experimental group and the control group were comparable(p>0.05).After treatment,the scores of qol in both groups were significantly improved.Compared with the level after treatment,the results showed that the level of the experimental group was significantly lower than that of the control group in the aspects of ankle or leg edema,fatigue,fatigue or decreased energy,asthma,forced sitting or lying down during the day and poor sleep at night,that is,the improvement of the experimental group was better than the control group.10.There were 36 patients in each group,with a total effective rate of 97.2% in the experimental group and 77.8% in the control group.There were statistically significant differences between the two groups(P < 0.05),indicating that the improvement effect of TCM symptoms in the experimental group was better than that in the control group.Conclusion:1.Yangxin decoction has obvious clinical effect in the treatment of chronic heart failure combined with ventricular premature beat due to deficiency of qi and blood.2.Yangxin decoction taste of chronic heart failure with blood deficiency type of TCM syndrome with ventricular premature beat,6-minute walking test results,left ventricular ejection fraction,nt-probnp,ventricular frequency,quality of life scores are significantly improved,and no adverse reactions,small side effects,low price,obvious effect.Therefore,yangxin decoction has a good effect in treating chronic heart failure with ventricular premature beat. |
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