| Objective1.Based on the Traditional Chinese Medicine?TCM?"treatment in accordance with seasonal conditions"and"prevention treatment of disease"theory,the application of summer winter disease cure of acupoint sticking with Liuweibuqi granules comprehensive intervention in patients with COPD stabilization lung-kidney Qi deficiency syndrome in clinical research,in-depth observation of COPD stabilization of lung function in patients with lung-kidney Qi deficiency syndrome,the number of exacerbations,the average hospitalization days,life quality,syndrome of TCM and western medicine symptoms and signs integral change,and a preliminary comprehensive judgement and evaluating the overall efficacy of the characteristics of traditional Chinese medicine therapy for COPD stabilization and to explore its clinical application value.2.To explore the effects of summer acupoint application and comprehensive intervention of Liuweibuqi granules on the levels of SP-D,TGF-?1 and IL-32 in peripheral blood of COPD patients with lung-kidney Qi deficiency syndrome in stable stage,and to provide a scientific basis for comprehensive intervention of stable COPD by TCM characteristic therapy.Methods1.The 64 patients with stable COPD?lung-kidney Qi deficiency syndrome?were collected from respiratory department of three hospitals,including the First Hospital Affiliated to Anhui University of Chinese Medicine,Hefei First People's Hospital and the Hefei Second People's Hospital.According to the random number table method,32cases in the treatment group and 32 cases in the control group were divided into two groups.During the experiment,2 cases in the treatment group fell off and 2 cases in the control group fell off.Finally,30 cases in the treatment group and 30 cases in the control group were used as statistical data sources.The treatment group was given basic therapy of seretide inhalation,Starting from the summer solstice,acupoint application of Traditional Chinese Medicine was applied for 2 months.Liuweibuqi granules was given orally for 2 months at the winter solstice,and the control group was treated with Seretide inhalation for 2 months.After Liuweibuqi granules treatment,two groups were followed up for 1 years.2.The lung function,the number of exacerbations annually,the average hospitalization days,CAT scores,syndrome of TCM and western medicine symptoms and signs integral changes were recored at different observation points.In the before and after treatment,2 months,5 months,8 months and one year observation records in the two groups patients with different observation points.In addition,the levels of SP-D,TGF-?1 and IL-32 in peripheral blood were measured different observation points in the before and after treatment,5 months.SPSS22.0 statistical software was used to analyze and process the data.Results1.Comparison of overall efficacy and symptom improvement:The total effective rate?86.7%?in the treatment group was higher than that in the control group?73.3%?,and the efficacy was better than that in the control group?Z=-2.671,P<0.05?.The scores of TCM syndromes and western medicine symptoms and signs in the two groups after treatment,at the second month,the fifth month and the eighth month after treatment were all lower than those before treatment?P<0.05?.The treatment group was less than the control group,and the differences were statistically significant?P<0.05?.2.Comparison of lung function:Patients in the control group were slightly higher at the2 months and the 5 months after treatment,and slightly lower at the 8 months after treatment,and showed a downward trend from the 5 months,but there was no statistical difference?P>0.05?.In the treatment group,the mean values of FEV1 and FEV1/FVC were slightly higher at 2 months,5 months and 8 months after treatment than before treatment.Compared with the control group,although the mean values of FEV1 and FEV1/FVC were slightly increased and the decline of lung function was inhibited to some extent,there was no statistical difference?P>0.05?.3.Comparison of the number of exacerbations annually and average hospitalization days:By reviewing the history of exacerbations during the first one year of treatment in patients with and one year after treatment with a history of acute aggravating found,compared two groups of patients after treatment of acute aggravating number annually and the average hospitalization days before the treatment of exacerbations were decreased?P<0.05?,and the treatment group decreased more significantly than control group?P<0.05?.4.Comparison of quality of life:CAT scores of patients in the treatment group after treatment,at the 2 months,the 5 months and the 8 months after treatment were all lower than those in the control group,and the differences were statistically significant?P<0.05?.CAT scores of the two groups after treatment,at the 2 months after treatment and at the 5 months after treatment were lower than those before treatment,showing statistical difference?P<0.05?.There was a difference between the treatment group and the control group at the 8th month?P<0.05?,while there was a difference between the control group and the treatment group at the 8 months after treatment,but the difference was not statistically significant?P>0.05?.5.Comparison of SP-D,TGF-?1 and IL-32 levels in peripheral blood:In the treatment group were lower than those in the control group?P<0.05?,and the levels of SP-D,TGF-?1 and IL-32 in the treatment group were lower than those in the control group after treatment?P<0.05?;the levels of SP-D,TGF-?1 and IL-32 in the treatment group were lower than those before treatment?P<0.05?;the levels of SP-D,TGF-?1 and IL-32 in the treatment group were lower than those before treatment?P<0.05?.The 5months after treatment were lower than before,but there was no statistical difference?P>0.05?.Conclusion1.Based on the thought of"treatment in accordance with seasonal conditions"and"prevention treatment of disease"in TCM,the curative effect of comprehensive intervention of summer acupoint application and winter treatment of Liuweibuqi granules on stable COPD patients?Lung-kidney Qi Deficiency Syndrome?is definite,and which can inhibit lung function decline,reduce the number of exacerbations,shorten the average hospitalization days,relieve symptoms,and improve quality of life.It has the advantage of TCM characteristic treatment and promotion value.2.The comprehensive treatment of winter acupoint application and winter treatment with liuweibuqi granules can effectively reduce the expression levels of SP-D,TGF-?1,and IL-32 in stable COPD patients?lung-kidney Qi deficiency syndrome?,which may alleviate airway or lung inflammation,so as to alleviate or inhibit the progress of the disease. |
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