| 1 Research objectionsThe clinical effect of treating severe KOA was observed in the treatment of washing out by the use of the Chinese herbs Haitongpitang.2 Research contents and methods.In the randomized controlled clinical study,we selected patients from the department of orthopedics.Wangjing Hospital of the CACMS.In accordance with the inclusion and exclusion criteria of this subject,a total of 60 cases of severe KOA case data were selected,and the random number method was used to divide the patients into the experimental group and the control group in 30 cases.On the premise of basic treatment(including health education,quadriceps muscle function exercise,0.5g of sulphate glucosamine capsules oraled three times a day),the test group was washed by the Xibitang,by the way,the control group accepted the washing of Haitongpitang.The two groups of herbs were uniformly used in granule preparation,which was made by the pharmacy of Wangjing Hospital of the CACMS.To dissolve the herbs in water.when the temperature drops to about 30? to 40?,we make the knee wrapped with a towel,and pour the liquid into the affected area constantly,1 dose daily,2 times a day.20 minutes each time,we continue use 2 weeks for 1 course of treatment.Before treatment.1 week and 2 weeks of treatment,the 3 time points were observed.The VAS score,the ISOA score and the WOMAC scale were recorded at each time point to carry out the scoring statistical analysis,the ISOA score and the WOMAC scale were calculated using nimodipine method in the 1 week and 2 weeks.3 Research results3.1 Statistical descriptionA total of 60 patients with severe KOA were actually observed.There were 30 patients in the test group(25 cases were female,5 cases were male),whose average age was 67.77±11.14 vears and average duration was 36.28±57.20 months;and there were 30 cases in the control group,including 25 female and 5 male,whose average age was 65.10±8.68 years,and average duration was 63.83±83.49 months.It was found that prior to the treatment of the two groups,that sex.age.course.VAS score and WOMAC score of the two groups had no statistically significant(P>0.05),the baseline levels were comparable.3.2 Effect evalutionThrough the analysis of the eficacy evaluation,compared in the first week and the second week,it can be found that the therapeutic effect indexes of the two groups had no significant difference(P>0.05).By ISOA scale assessment,one week after the treatment,the treatment group had 29 cases invalid(96.7%),1 case effective(3.3%),0 case markedly effective and curative,and the control group had 29 cases invalid(96.7%),1 case effective(3.3%),0 cases markedly effective and curative,whose total effective rates were 3.3%,33%,(P>0.05).Two weeks later,the test aroup had 24 cases invalid(80.0%),6 cases effective(20.0%),0 cases markedly effective and curative,the control group had 28 cases invalid(93.3%).1 cases effective(3.3%),1 case(3.3%)markedly effective,0 case curative.whose total effective rates were 20.0%,6.6%,P>0.05.There was no significant difference in the efficacy of ISOA scale between the two groups.Assessed by the WOMAC scale,after one week to treat,in the treatment group.26 cases were invalid(86.7%),3 patients were effective(10.0%),1 case was markedly effective(3.3%).0 was healed.In the control group,27 cases were invalid(90.0%),2 cases were effective(6.7%),1 case was markedly effective(3.3%),0 was healed,total effective rates were 13.3%,10.0%.which were respectively(P>0.05).And two weeks after the treatment,the total effective rates were 60.0%,56.6%,respectively.P>0.05.Every visit points's curative effect analysed by WOMAC questionnaire of two groups had no obvious difference.3.3 Comparision of the scale scores before and after treatment of two groupsThe results of the VAS scale in both groups were to be found,and the VAS were all sisnificantly reduced after one week's and two weeks's treatment(P<0.01),and there was no significant difference between the two groups(P>0.05)To analysis the ISOA scale,the test group had a sisnificant decline in daily life scores in the second week,by the wav,the rest scores of the grade,the symptoms,and the maximum walking distance had been sianificantlv decreased in the first week and the second week.In the control group,there was no significant decrease in the first week about the scores of the symptoms,the maximum walking distance and the daily life(P>0.05),in the second week.the decrease was significant(P<0.01),the total score was decreased after the first week's treatment(P<0.05)and significantly decreased after the second week's treatment(P<0.01).In comparison between groups,before treatment.the difference in total score,symptoms and signs score and maximum walking distance score was obvious(P<0.05).which was not comparable.It is comparable to that score for the daily life before treatment(P=0.096>0.05),and there was no significant difference between the two groups in the first week and the second week after treatment(P>0.05).For the study of the WOMAC scale,the test group's stiffness rating began to drop significantly after two weeks,and the rest of the total score,the pain,the daily life difficulty rating were significantly reduced after one week's treatment.In the control group,the score of totalrpain,stiffness and daily life difficulty were all significantly decreased after a week(P<0.01),and there was no significant difference between the two groups(P>0.05).By using a variety of rating scales and the results of the two groups,analyzing the difference of each points of view,the test group's total score,symptom score in the first and second weeks,the maximum walking distance score in the second week,of the ISOA scale,were better than the control group(P<0.05)4 Conclusions4.1 The washing out treatment of the knee can improve the condition of severe KOA by using the Xibitang and the Haitongpitang.And the effect of continue use is more significant than that of short-term use.4.2 The treatment of Xibitang was better than that of Haitongpitang.4.3 The safety of the treatment was high,and no obvious adverse reactions were observed. |
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