Relationship Between CXCR7 And Liver Or Lung Metastasis Of Colorectal Cancer

Background&Aims:Chemokines and chemokine receptors are closely related to the occurrence,development and metastasis of tumors,and they are important factors in regulating the malignant biological behaviors of tumors.CXCR7 is a chemokine receptor that has been found to have important function in tumors in recent years.However,the relationship between the expression and function of CXCR7 in colorectal cancer and its correlation with cancer progression are not clear.This article intends to study the changes of CXCR7 expression in the process of liver or lung metastasis of colorectal cancer,and to explore the value of the substance in the liver or lung metastasis of colorectal cancer.Methods:we enrolled the colorectal cancer patients with lung or liver metastasis,collected their cancerous tissue,para-tumor colorectal tissue,metastatic lymph node and metastatic tissue,the control group enrolled the colorectal cancer patients without metastasis,collected their cancerous tissue,para-tumor colorectal tissue,metastatic lymph node tissue,Clinical data including age,sex,tumor location,size,pathological type,etc.were recorded in detail.Immunohistochemical staining was used to compare the positive rate of CXCR7 expression in colorectal cancer tissues of metastasis group and control group.The correlation between CXCR7 expression and clinicopathological features was analyzed statistically.Results:The results of IHC showed that the expression of CXCR7 in the primary foci were higher of metastasis group compared with control group,The comparison between the two is statistically significant.Conclusions:CXCR7 promotes distant metastasis of colorectal cancer,and the specific mechanism remains to be further explored.